Relationship between clinical data and gene expression in the HER2/ErbB2-dependent signaling pathway in patients with acute heart failure

Anticancer treatment with the human epidermal growth factor receptor (HER) 2 inhibitors can lead to significant myocardial dysfunction. The primary aim of the study was to estimate the possible association between gene expression in the ErbB signaling pathway and selected clinical event data in pati...

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Bibliographic Details
Published in:Journal of applied genetics 2013-11, Vol.54 (4), p.447-453
Main Authors: Szmit, Sebastian, Jank, Michał, Maciejewski, Henryk, Balsam, Paweł, Łój, Magdalena, Filipiak, Krzysztof J, Motyl, Tomasz, Opolski, Grzegorz
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biomedical and Life Sciences
blood
Care and treatment
epidermal growth factor
Gene expression
Genes
Genetic research
Heart failure
Human Genetics
Human Genetics • Original Paper
humans
Instrument industry
Life Sciences
males
Microbial Genetics and Genomics
patients
Pertuzumab
Plant Genetics and Genomics
prognosis
therapeutics
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Summary:Anticancer treatment with the human epidermal growth factor receptor (HER) 2 inhibitors can lead to significant myocardial dysfunction. The primary aim of the study was to estimate the possible association between gene expression in the ErbB signaling pathway and selected clinical event data in patients with acute heart failure. Twenty-four patients (19 males), aged 68.6 ± 12.3 years, were diagnosed and treated due to acute heart failure. The globaltest method was used for the correlation between blood nuclear cells’ gene expression in the ErbB pathway (KEGG pathway id 04012) and important clinical data. Decreased expression of ErbB2/HER2 was found to be associated with the release of troponin and the need for inotropic support, whereas decreased neuregulin 1 (NRG1) expression was found to be associated with a decrease of ejection fraction below 40 % (globaltest p-value < 0.05). In summary, the ErbB signaling pathway and, especially, HER2/ErbB2 receptor expression are significantly associated with some of the recognized, clinically significant parameters of patients with acute heart failure. Evaluation of the molecular function of the HER2 receptor may be essential for the prognosis and targeted therapy of heart diseases.
ISSN:1234-1983
2190-3883
DOI:10.1007/s13353-013-0164-y