The Changing Landscape of Type 1 Diabetes: Recent Developments and Future Frontiers

Type 1 diabetes (T1D) research has made great strides over the past decade with advances in understanding the pathogenesis, natural history, candidate environmental exposures, exposure triggering time, disease prediction, and diagnosis. Major monitoring efforts have provided baseline historical meas...

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Bibliographic Details
Published in:Current diabetes reports 2013-10, Vol.13 (5), p.642-650
Main Authors: Vehik, Kendra, Ajami, Nadim J., Hadley, David, Petrosino, Joseph F., Burkhardt, Brant R.
Format: Article
Language:English
Subjects:
Diabetes
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Diabetes Mellitus, Type 1 - microbiology
Diabetes Mellitus, Type 1 - pathology
Humans
Medicine
Medicine & Public Health
Metabolome
Microbiota
Pathogenesis of Type 1 Diabetes (D Dabelea
Section Editor
T-Lymphocytes - immunology
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Summary:Type 1 diabetes (T1D) research has made great strides over the past decade with advances in understanding the pathogenesis, natural history, candidate environmental exposures, exposure triggering time, disease prediction, and diagnosis. Major monitoring efforts have provided baseline historical measures, leading to better epidemiological studies incorporating longitudinal biosamples (ie, biobanks), which have allowed for new technologies (‘omics’) to further expose the etiological agents responsible for the initiation, progression, and eventual clinical onset of T1D. These new frontiers have brought forth high-dimensionality data, which have furthered the evidence of the heterogeneous nature of T1D pathogenesis and allowed for a more mechanistic approach in understanding the etiology of T1D. This review will expand on the most recent advances in the quest for T1D determinants, drawing upon novel research tools that epidemiology, genetics, microbiology, and immunology have provided, linking them to the major hypotheses associated with T1D etiology, and discussing the future frontiers.
ISSN:1534-4827
1539-0829
1539-0829
DOI:10.1007/s11892-013-0406-8