Seizure control following radiotherapy in patients with diffuse gliomas: a retrospective study

• Published in: Neuro-oncology (Charlottesville, Va.) Va.), 2013-12, Vol.15 (12), p.1739-1749
• Main Authors: Rudà, Roberta, Magliola, Umberto, Bertero, Luca, Trevisan, Elisa, Bosa, Chiara, Mantovani, Cristina, Ricardi, Umberto, Castiglione, Anna, Monagheddu, Chiara, Soffietti, Riccardo
• Format: Article
• Language: English
• Subjects: Adult; Brain Neoplasms - complications; Brain Neoplasms - pathology; Brain Neoplasms - therapy; Clinical Investigations; Female; Follow-Up Studies; Glioma - complications; Glioma - pathology; Glioma - therapy; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Grading; Prognosis; Radiotherapy; Retrospective Studies; Seizures - etiology; Seizures - prevention & control; Seizures - radiotherapy; Young Adult
• ISSN: 1522-8517; 1523-5866
• DOI: 10.1093/neuonc/not109

Little information is available regarding the effect of conventional radiotherapy on glioma-related seizures. In this retrospective study, we analyzed the seizure response and outcome following conventional radiotherapy in a cohort of 43 patients with glioma (33 grade II, 10 grade III) and medically intractable epilepsy. At 3 months after radiotherapy, seizure reduction was significant (≥ 50% reduction of frequency compared with baseline) in 31/43 patients (72%) of the whole series and in 25/33 patients (76%) with grade II gliomas, whereas at 12 months seizure reduction was significant in 26/34 (76%) and in 19/25 (76%) patients, respectively. Seizure reduction was observed more often among patients displaying an objective tumor response on MRI, but patients with no change on MRI also had a significant seizure reduction. Seizure freedom (Engel class I) was achieved at 12 months in 32% of all patients and in 38% of patients with grade II tumors. Timing of radiotherapy and duration of seizures prior to radiotherapy were significantly associated with seizure reduction. This study showed that a high proportion of patients with medically intractable epilepsy from diffuse gliomas derive a significant and durable benefit from radiotherapy in terms of epilepsy control and that this positive effect is not strictly associated with tumor shrinkage as shown on MRI. Radiotherapy at tumor progression seems as effective as early radiotherapy after surgery. Prospective studies must confirm and better characterize the response to radiotherapy.