Ranibizumab in choroidal neovascularisation associated with ocular sarcoidosis

An 81-year-old Caucasian man with a history of chronic bilateral panuveitis associated with sarcoidosis presented with visual acuity 1.0 LogMAR in the right and 0.5 LogMAR in the left eye. Following fluoroscein angiogram bilateral choroidal neovascular membrane was established. Treatment was initiat...

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Bibliographic Details
Published in:BMJ case reports 2013-11, Vol.2013, p.bcr2013010288
Main Authors: Konidaris, Vasileios Efstathios, Empeslidis, Theodoros
Format: Article
Language:English
Subjects:
80 Years
Aged, 80 and over
Antibodies, Monoclonal, Humanized - administration & dosage
Antibodies, Monoclonal, Humanized - therapeutic use
Choroid - blood supply
Choroid - pathology
Choroid Diseases - complications
Choroidal Neovascularization - diagnosis
Choroidal Neovascularization - drug therapy
Choroidal Neovascularization - etiology
Diabetic retinopathy
Europe (West)
Fluorescein Angiography
Fundus Oculi
Humans
Intravitreal Injections
Lymphatic system
Macular degeneration
Male
Novel Treatment (New Drug/Intervention
Established Drug/Procedure in New Situation)
Ranibizumab
Sarcoidosis
Sarcoidosis - complications
Uveitis - etiology
White
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Summary:An 81-year-old Caucasian man with a history of chronic bilateral panuveitis associated with sarcoidosis presented with visual acuity 1.0 LogMAR in the right and 0.5 LogMAR in the left eye. Following fluoroscein angiogram bilateral choroidal neovascular membrane was established. Treatment was initiated with a course of 3 monthly intravitreal injections of ranibizumab 0.5 mg in 0.05 mL bilaterally; oral prednisolone 30 mg/day on tapering doses controlled the ocular inflammation prior to the treatment with intravitreal injections. An additional two intravitreal ranibizumab injections were administered in the right eye. Fibrotic tissue in the posterior pole bilaterally was present on funduscopy following ranibizumab treatment. Visual acuity was LogMAR 1.6 in the right and 1.0 LogMAR in the left eye in 1 year follow-up. This case report summarises the issues of choroidal neovascularisation as a complication secondary to panuveitis associated with sarcoidosis and highlights the treatment of this complication with antivascular endothelial growth factor agents.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2013-010288