Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus

Highlights • Grin2b / Nr2b and Bdnf DNA methylation is altered in the epileptic hippocampus. • Grin2b / Nr2b and Bdnf gene and protein expression is correlated with DNA methylation. • SE triggered early and late increases in DNA methylating and demethylating enzymes. • DNMT inhibition altered SE-ind...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2013-09, Vol.248, p.602-619
Main Authors: Ryley Parrish, R, Albertson, A.J, Buckingham, S.C, Hablitz, J.J, Mascia, K.L, Davis Haselden, W, Lubin, F.D
Format: Article
Language:English
Subjects:
Animals
Bdnf
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Cytidine - analogs & derivatives
Cytidine - pharmacology
DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors
DNA demethylation
DNA Methylation
Electroencephalography
epigenetics
epilepsy
Epilepsy, Temporal Lobe - metabolism
Grin2b/Nr2b
Hippocampus - metabolism
Kainic Acid - toxicity
Male
Neurology
Rats
Receptors, N-Methyl-D-Aspartate - genetics
Receptors, N-Methyl-D-Aspartate - metabolism
seizures
Seizures - metabolism
Status Epilepticus - chemically induced
Status Epilepticus - genetics
Status Epilepticus - metabolism
Status Epilepticus - physiopathology
Transcription Factor AP-2 - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Grin2b / Nr2b and Bdnf DNA methylation is altered in the epileptic hippocampus. • Grin2b / Nr2b and Bdnf gene and protein expression is correlated with DNA methylation. • SE triggered early and late increases in DNA methylating and demethylating enzymes. • DNMT inhibition altered SE-induced hippocampal methylation and synaptic plasticity. • DNMT inhibition restored decreases in AP2alpha binding at the Nr2b gene promoter.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.06.029