Early working memory as a racially and ethnically neutral measure of outcome in extremely preterm children at 18–22 months

• Published in: Early human development 2013-12, Vol.89 (12), p.1055-1061
• Main Authors: Lowe, Jean R, Duncan, Andrea Freeman, Bann, Carla M, Fuller, Janell, Hintz, Susan R, Das, Abhik, Higgins, Rosemary D, Watterberg, Kristi L
• Format: Article
• Language: English
• Subjects: Advanced Basic Science; Attention - physiology; Child Development - physiology; Cohort Studies; Educational Status; Ethnicity; Humans; Infant; Infant, Extremely Premature - physiology; Logistic Models; Male; Memory, Short-Term - physiology; Neonatal and Perinatal Medicine; Neuropsychological Tests - standards; Racial Groups; Sex Factors
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/j.earlhumdev.2013.08.009

Abstract Background Difficulties with executive function have been found in preterm children, resulting in difficulties with learning and school performance. Aim This study evaluated the relationship of early working memory as measured by object permanence items to the cognitive and language scores on the Bayley Scales-III in a cohort of children born extremely preterm. Study design Logistic regression models were conducted to compare object permanence scores derived from the Bayley Scales-III by race/ethnicity and maternal education, controlling for medical covariates. Subjects Extremely preterm toddlers (526), who were part of a Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's multi-center study, were evaluated at 18–22 months corrected age. Outcome measures Object permanence scores derived from the Bayley Developmental Scales were compared by race/ethnicity and maternal education, controlling for medical covariates. Results There were no significant differences in object permanence mastery and scores among the treatment groups after controlling for medical and social variables, including maternal education and race/ethnicity. Males and children with intraventricular hemorrhage, retinopathy of prematurity, and bronchopulmonary dysplasia were less likely to demonstrate object permanence mastery and had lower object permanence scores. Children who attained object permanence mastery had significantly higher Bayley Scales-III cognitive and language scores after controlling for medical and socio-economic factors. Conclusions Our measure of object permanence is free of influence from race, ethnic and socio-economic factors. Adding this simple task to current clinical practice could help detect early executive function difficulties in young children.