Umbelliferone β-D-galactopyranoside from Aegle marmelos (L.) corr. an ethnomedicinal plant with antidiabetic, antihyperlipidemic and antioxidative activity

• Published in: BMC complementary and alternative medicine 2013-10, Vol.13 (1), p.273-273, Article 273
• Main Authors: Kumar, Vikas, Ahmed, Danish, Verma, Amita, Anwar, Firoz, Ali, Mohammed, Mujeeb, Mohd
• Format: Article
• Language: English
• Subjects: Aegle - chemistry; Animals; Antioxidants - administration & dosage; Blood Glucose - analysis; Catalase - pharmacology; Cholesterol, HDL - blood; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - metabolism; Galactose - administration & dosage; Glucose Tolerance Test; Glucose-6-Phosphatase - blood; Glycated Hemoglobin A - metabolism; Humans; Hypoglycemic Agents - administration & dosage; Hypolipidemic Agents - administration & dosage; Insulin - blood; Liver - drug effects; Liver - metabolism; Male; Plant Extracts - administration & dosage; Plants, Medicinal - chemistry; Rats; Triglycerides - blood; Umbelliferones - administration & dosage
• ISSN: 1472-6882; 1472-6882
• DOI: 10.1186/1472-6882-13-273

Aegle marmelos (L.) Corr. (Rutaceae), commonly known as bael, is used to treat fevers, abdomen pain, palpitation of the heart, urinary troubles, melancholia, anorexia, dyspepsia, diabetes and diarrhea in Indian traditional systems of medicine. The object of the present study was to evaluate the antidiabetic, antihyperlipidemic and antioxidant oxidative stress of umbelliferone β-D-galactopyranoside (UFG) from stem bark of Aegle marmelos Correa. in STZ (streptozotocin) induced diabetic rat. Diabetes was induced in rat by single intraperitoneal injection of STZ (60 mg/kg). The rat was divided into the following groups; I - normal control, II - diabetic control, III - UFG (10 mg/kg), IV - UFG (20 mg/kg), V - UFG (40 mg/kg), VI - Glibenclamide (10 mg/kg, p.o., once a daily dose). Diabetes was measured by change the level blood glucose, plasma insulin and the oxidative stress were assessed in the liver by estimation of the level of antioxidant markers i.e. superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and Malondialdehyde (MDA) and antihyperlipidemic effect was measured by estimation of total cholesterol, triglycerides, LDL (low density lipoprotein) cholesterol, HDL (high density lipoprotein) cholesterol, VLDL (very low density lipoprotein) cholesterol. However in a study, the increased body weight was observed and utilization of glucose was in the oral glucose tolerance test. Daily oral administration of different dose of UFG for 28 days showed significantly (P