HER2 status in advanced gastric carcinoma: A retrospective multicentric analysis from Sicily

According to the ToGA trial, HER2 has been shown to be predictive for the success of treatment with trastuzumab in advanced gastric cancer (AGC). A number of studies have analyzed HER-2/neu overexpression in gastric carcinoma and identified the rate of HER2 positivity to be markedly varied. To date,...

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Bibliographic Details
Published in:Oncology letters 2013-12, Vol.6 (6), p.1591-1594
Main Authors: IENI, A, BARRESI, V, GIUFFRÈ, G, CARUSO, R.A, LANZAFAME, S, VILLARI, L, SALOMONE, E, ROZ, E, CABIBI, D, FRANCO, V, CERTO, G, LABATE, A, NAGAR, C, MAGLIOLO, E, BROGGI, B, FAZZARI, C, ITALIA, F, TUCCARI, G
Format: Article
Language:English
Subjects:
Antigens
Cancer therapies
Chemotherapy
Cloning
Cytoplasm
gastric adenocarcinoma
Gastric cancer
Gene amplification
HER2 status
Immunotherapy
Laboratories
Monoclonal antibodies
Mortality
Multivariate analysis
Oncology
Proteins
Sicily
Statistical analysis
Studies
Targeted cancer therapy
trastuzumab
Tumors
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Summary:According to the ToGA trial, HER2 has been shown to be predictive for the success of treatment with trastuzumab in advanced gastric cancer (AGC). A number of studies have analyzed HER-2/neu overexpression in gastric carcinoma and identified the rate of HER2 positivity to be markedly varied. To date, the prevalence of HER2 overexpression in Sicilian people with AGC is unknown. Therefore, in the present study, a retrospective immunohistochemical analysis of HER2 was performed in a cohort of 304 AGC samples that were obtained from the archives of 10 Sicilian anatomopathological diagnostic units in order to verify the positive rate of HER2-positive cases. Furthermore, the characteristics of histotype, grade, stage and Ki-67 expression were also analyzed. HER2 overexpression was encountered in 17.43% of all the gastric adenocarcinomas, which was consistent with the results that have been reported elsewhere in the literature. A progressive increase in HER2 overexpression was observed, from the poorly cohesive histotype to the tubular adenocarcinomas and gastric hepatoid adenocarcinomas. HER2 overexpression was significantly associated with a high grade, advanced stage and high Ki-67 labeling index. Further investigations performed jointly by pathologists and oncologists within the geographical area of the present study should confirm that the association of trastuzumab with chemotherapy results in an improvement of survival in patients with AGC.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2013.1611