Cardiovascular Disease in Latin American Patients with Systemic Lupus Erythematosus: A Cross-Sectional Study and a Systematic Review

Objective. This study was performed to determine the prevalence of and associated risk factors for cardiovascular disease (CVD) in Latin American (LA) patients with systemic lupus erythematosus (SLE). Methods. First, a cross-sectional analytical study was conducted in 310 Colombian patients with SLE...

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Bibliographic Details
Published in:Autoimmune Diseases 2013-01, Vol.2013 (2013), p.199-218
Main Authors: Amaya-Amaya, Jenny, Sarmiento-Monroy, Juan Camilo, Caro-Moreno, Julián, Molano-González, Nicolás, Mantilla, Rubén D., Rojas-Villarraga, Adriana, Anaya, Juan-Manuel
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Cigarette smoking
Coffee
Complications and side effects
Cross-sectional studies
Dyslipidemia
Genetic factors
Health aspects
Laboratories
Latin Americans
Literature reviews
Lupus
Medical research
Medicine, Experimental
Mortality
Pleural effusion
Public health
Risk factors
Socioeconomic factors
Systematic review
Systemic lupus erythematosus
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Summary:Objective. This study was performed to determine the prevalence of and associated risk factors for cardiovascular disease (CVD) in Latin American (LA) patients with systemic lupus erythematosus (SLE). Methods. First, a cross-sectional analytical study was conducted in 310 Colombian patients with SLE in whom CVD was assessed. Associated factors were examined by multivariate regression analyses. Second, a systematic review of the literature on CVD in SLE in LA was performed. Results. There were 133 (36.5%) Colombian SLE patients with CVD. Dyslipidemia, smoking, coffee consumption, and pleural effusion were positively associated with CVD. An independent effect of coffee consumption and cigarette on CVD was found regardless of gender and duration of disease. In the systematic review, 60 articles fulfilling the eligibility criteria were included. A wide range of CVD prevalence was found (4%–79.5%). Several studies reported ancestry, genetic factors, and polyautoimmunity as novel risk factors for such a condition. Conclusions. A high rate of CVD is observed in LA patients with SLE. Awareness of the observed risk factors should encourage preventive population strategies for CVD in patients with SLE aimed at facilitating the suppression of cigarette smoking and coffee consumption as well as at the tight control of dyslipidemia and other modifiable risk factors.
ISSN:2090-0430
2090-0422
2090-0430
DOI:10.1155/2013/794383