Meiosis I: when chromosomes undergo extreme makeover

The ultimate success of cell division relies on the accurate partitioning of the genetic material. Errors in this process occur in nearly all tumors and are the leading cause of miscarriages and congenital birth defects in humans. Two cell divisions, mitosis and meiosis, use common as well as unique...

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Bibliographic Details
Published in:Current opinion in cell biology 2013-12, Vol.25 (6), p.687-696
Main Authors: Miller, Matthew P, Amon, Angelika, Ünal, Elçin
Format: Article
Language:English
Subjects:
Cell Cycle Proteins - metabolism
Chromatids - genetics
Chromatids - metabolism
Chromosomal Proteins, Non-Histone - metabolism
Chromosome Segregation
Chromosomes - genetics
Chromosomes - metabolism
Cohesins
Humans
Internal Medicine
Kinetochores - metabolism
Meiosis - genetics
Mitosis - genetics
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Summary:The ultimate success of cell division relies on the accurate partitioning of the genetic material. Errors in this process occur in nearly all tumors and are the leading cause of miscarriages and congenital birth defects in humans. Two cell divisions, mitosis and meiosis, use common as well as unique mechanisms to ensure faithful chromosome segregation. In mitosis, alternating rounds of DNA replication and chromosome segregation preserve the chromosome complement of the progenitor cell. In contrast, during meiosis two consecutive rounds of nuclear division, meiosis I and meiosis II, follow a single round of DNA replication to reduce the chromosome complement by half. Meiosis likely evolved through changes to the mitotic cell division program. This review will focus on the recent findings describing the modifications that transform mitosis into meiosis.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2013.07.009