Evaluation of a Common Receptor-Complement Concept for Predicting the Antileukemic Activity of Nucleosides

The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a ``common receptor-complement feature'' has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the ``...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1979-08, Vol.76 (8), p.4075-4078
Main Authors: Townsend, Leroy B., Schram, Karl H., Beránek, Jirí
Format: Article
Language:English
Subjects:
Animals
Atoms
Biochemistry
Hydroxyls
Leukemia
Leukemia L1210 - drug therapy
Mice
Molecular Conformation
Nitrogen
Nucleosides
Nucleosides - metabolism
Nucleosides - therapeutic use
Oxygen
Purines
Receptors, Drug - metabolism
Structure-Activity Relationship
Sugars
Triangulation
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Summary:The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a ``common receptor-complement feature'' has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the ``receptor-complement feature'' as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.76.8.4075