Evaluation of a Common Receptor-Complement Concept for Predicting the Antileukemic Activity of Nucleosides

The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a ``common receptor-complement feature'' has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the ``...

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Published in:Proceedings of the National Academy of Sciences - PNAS 1979-08, Vol.76 (8), p.4075-4078
Main Authors: Townsend, Leroy B., Schram, Karl H., Beránek, Jirí
Format: Article
Language:English
Subjects:
Animals
Atoms
Biochemistry
Hydroxyls
Leukemia
Leukemia L1210 - drug therapy
Mice
Molecular Conformation
Nitrogen
Nucleosides
Nucleosides - metabolism
Nucleosides - therapeutic use
Oxygen
Purines
Receptors, Drug - metabolism
Structure-Activity Relationship
Sugars
Triangulation
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container_issue 8
container_start_page 4075
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 76
creator Townsend, Leroy B.
Schram, Karl H.
Beránek, Jirí
description The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a ``common receptor-complement feature'' has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the ``receptor-complement feature'' as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.
doi_str_mv 10.1073/pnas.76.8.4075
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source Open Access: PubMed Central; JSTOR Archival Journals and Primary Sources Collection
subjects Animals
Atoms
Biochemistry
Hydroxyls
Leukemia
Leukemia L1210 - drug therapy
Mice
Molecular Conformation
Nitrogen
Nucleosides
Nucleosides - metabolism
Nucleosides - therapeutic use
Oxygen
Purines
Receptors, Drug - metabolism
Structure-Activity Relationship
Sugars
Triangulation
title Evaluation of a Common Receptor-Complement Concept for Predicting the Antileukemic Activity of Nucleosides
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