High Frequency of False-Positive Hepatitis C Virus Enzyme-Linked Immunosorbent Assay in Rakai, Uganda

The prevalence of hepatitis C virus (HCV) infection in sub-Saharan Africa remains unclear. We tested 1000 individuals from Rakai, Uganda, with the Ortho version 3.0 HCV enzyme-linked immunosorbent assay. All serologically positive samples were tested for HCV RNA. Seventy-six of the 1000 (7.6%) parti...

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Bibliographic Details
Published in:Clinical infectious diseases 2013-12, Vol.57 (12), p.1747-1750
Main Authors: Mullis, Caroline E., Laeyendecker, Oliver, Reynolds, Steven J., Ocama, Ponsiano, Quinn, Jeffrey, Boaz, Iga, Gray, Ronald H., Kirk, Gregory D., Thomas, David L., Quinn, Thomas C., Stabinski, Lara
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Antibodies
Biological and medical sciences
BRIEF REPORT
Enzyme linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - statistics & numerical data
Enzymes
Epidemiology
False Positive Reactions
Female
Hepacivirus
Hepacivirus - immunology
Hepacivirus - isolation & purification
Hepatitis
Hepatitis C
Hepatitis C - diagnosis
Hepatitis C - epidemiology
Hepatitis C - immunology
Hepatitis C - virology
Hepatitis C Antibodies - blood
HIV
HIV Infections - blood
HIV Infections - etiology
HIV Infections - virology
Human viral diseases
Humans
Immunoassay
Infections
Infectious diseases
Liver
Male
Medical sciences
Middle Aged
Prevalence
Ribonucleic acid
RNA
RNA, Viral - blood
Seroepidemiologic Studies
Uganda - epidemiology
Viral diseases
Viral hepatitis
Viruses
Young Adult
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Description
Summary:The prevalence of hepatitis C virus (HCV) infection in sub-Saharan Africa remains unclear. We tested 1000 individuals from Rakai, Uganda, with the Ortho version 3.0 HCV enzyme-linked immunosorbent assay. All serologically positive samples were tested for HCV RNA. Seventy-six of the 1000 (7.6%) participants were HCV antibody positive; none were confirmed by detection of HCV RNA.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cit602