Renal angiotensin II type 1 receptor expression and associated hypertension in rats with minimal SHR nuclear genome

Angiotensin II (AII) has been linked as a causal factor in several experimental models of hypertension (HT) including Okamoto spontaneously hypertensive rats (SHR). The transmission and expression of AII type 1 receptors (AT1r) in SHR and the development of genetic HT remain unknown. It is hypothesi...

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Bibliographic Details
Published in:Physiological reports 2013-10, Vol.1 (5), p.e00104-n/a
Main Authors: Collett, Jason A., Hart, Anne K., Patterson, Elaine, Kretzer, Julie, Osborn, Jeffrey L.
Format: Article
Language:English
Subjects:
Age
Angiotensin
Angiotensin II
Angiotensin receptors
Blood pressure
Cardiovascular disease
Enzymes
Females
Gene expression
Genetic crosses
genetic hypertension
Genomes
Genotype & phenotype
Hypertension
Kidneys
Laboratory animals
Males
Original Research
Physiology
Polymerase chain reaction
Renin
renin–angiotensin system
Rodents
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Summary:Angiotensin II (AII) has been linked as a causal factor in several experimental models of hypertension (HT) including Okamoto spontaneously hypertensive rats (SHR). The transmission and expression of AII type 1 receptors (AT1r) in SHR and the development of genetic HT remain unknown. It is hypothesized that tissue‐specific expression of renin–angiotensin system (RAS) genes derived from SHR are linked to HT in offspring of SHR crossed with Brown Norway (BN) rats. Hypertensive female progeny of BN/SHR matings was backcrossed with founder BN males to generate the F1 and five backcross generations (BN/SHR‐mtSHR). Progeny were phenotyped according to normotension (NT: systolic arterial pressure [SAP] ≤ 124 mmHg), borderline hypertension (BHT: 124 ≤ SAP 
ISSN:2051-817X
2051-817X
DOI:10.1002/phy2.104