Urinary tuberculosis is associated with the development of urothelial carcinoma but not renal cell carcinoma: a nationwide cohort study in Taiwan

Background: Obstructive uropathy and chronic urinary tract infection increase the risk of urinary tract cancer. Urinary tuberculosis (UTB) can cause chronic urinary tract inflammation, lead to obstructive uropathy, and potentially contribute to the development of urinary tract cancer. However, the a...

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Bibliographic Details
Published in:British journal of cancer 2013-11, Vol.109 (11), p.2933-2940
Main Authors: Lien, Y-C, Wang, J-Y, Lee, M-C, Shu, C-C, Chen, H-Y, Hsieh, C-H, Lee, C-H, Lee, L-N, Chao, K-M
Format: Article
Language:English
Subjects:
692/699/255/1856
692/699/2768
692/699/67/2324
692/699/67/589
Adult
Aged
Arsenic
Bacterial diseases
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Buddhism
Cancer Research
Carcinoma, Renal Cell - epidemiology
Carcinoma, Transitional Cell - epidemiology
Cohort analysis
Cohort Studies
Drug Resistance
Epidemiology
Female
Hospitals
Human bacterial diseases
Humans
Infectious diseases
Inflammation
Internal medicine
Kidney cancer
Kidney diseases
Kidney Neoplasms - epidemiology
Male
Medical research
Medical sciences
Medicine
Middle Aged
Molecular Medicine
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Mycobacterium
National health insurance
Oncology
Risk factors
Taiwan - epidemiology
Tuberculosis
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Urogenital - epidemiology
Tumors
Urinary tract diseases
Urinary tract infections
Urinary Tract Infections - epidemiology
Urogenital system
Urologic Neoplasms - epidemiology
Urothelium - pathology
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Summary:Background: Obstructive uropathy and chronic urinary tract infection increase the risk of urinary tract cancer. Urinary tuberculosis (UTB) can cause chronic urinary tract inflammation, lead to obstructive uropathy, and potentially contribute to the development of urinary tract cancer. However, the association between UTB and urinary tract cancer has not been studied. Methods: This study enrolled 135 142 tuberculosis (TB) cases (male, 69%) from a nationwide health insurance research database in Taiwan and investigated the risk factors for urinary tract cancer, with emphasis on a history of UTB. The incidence of urinary tract cancer in the general population without TB was also calculated for comparison. Results: The TB patients had a mean age of 57.5±19.5 years. Of the 1287 UTB and 133 855 non-UTB patients, 15 (1.2%) and 396 (0.3%) developed urothelial carcinoma, respectively ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2013.538