A pH-Sensitive, Biobased Calcium Carbonate Aragonite Nanocrystal as a Novel Anticancer Delivery System

The synthesised biobased calcium carbonate nanocrystals had demonstrated to be an effective carrier for delivery of anticancer drug doxorubicin (DOX). The use of these nanocrystals displayed high levels of selectivity and specificity in achieving effective cancer cell death without nonspecific toxic...

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Bibliographic Details
Published in:BioMed research international 2013-01, Vol.2013 (2013), p.1-10
Main Authors: Zakaria, Zuki Abu Bakar, Tengku Ibrahim, Tengku Azmi, Ismail, Maznah, Shafiu Kamba, Abdullahi
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antitumor agents
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Calcium carbonate
Calcium Carbonate - administration & dosage
Calcium Carbonate - chemistry
Cell Line, Tumor
Doxorubicin - administration & dosage
Doxorubicin - chemistry
Drug Delivery Systems
Drugs
Female
Health aspects
Humans
Hydrogen-Ion Concentration
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Vehicles
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Summary:The synthesised biobased calcium carbonate nanocrystals had demonstrated to be an effective carrier for delivery of anticancer drug doxorubicin (DOX). The use of these nanocrystals displayed high levels of selectivity and specificity in achieving effective cancer cell death without nonspecific toxicity. These results confirmed that DOX was intercalated into calcium carbonate nanocrystals at high loading and encapsulation efficiency (4.8 and 96%, resp.). The CaCO3/DOX nanocrystals are relatively stable at neutral pH (7.4), resulting in slow release, but the nanocrystals progressively dissociated in acidic pH (4.8) regimes, triggering faster release of DOX. The CaCO3/DOX nanocrystals exhibited high uptake by MDA MB231 breast cancer cells and a promising potential delivery of DOX to target cells. In vitro chemosensitivity using MTT, modified neutral red/trypan blue assay, and LDH on MDA MB231 breast cancer cells revealed that CaCO3/DOX nanocrystals are more sensitive and gave a greater reduction in cell growth than free DOX. Our findings suggest that CaCO3 nanocrystals hold tremendous promise in the areas of controlled drug delivery and targeted cancer therapy.
ISSN:2314-6133
2314-6141
DOI:10.1155/2013/587451