The association of high-sensitivity c-reactive protein and other biomarkers with cardiovascular disease in patients treated for HIV: a nested case-control study

Elevated high-sensitivity C-reactive protein (hsCRP) increases the risk of cardiovascular disease (CVD) in the general population, but its role as a predictive marker in HIV-positive patients remains unclear. Aim of the study was to evaluate whether hsCRP or other biomarkers are independent predicto...

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Published in:BMC infectious diseases 2013-09, Vol.13 (1), p.414-414, Article 414
Main Authors: De Luca, Andrea, de Gaetano Donati, Katleen, Colafigli, Manuela, Cozzi-Lepri, Alessandro, De Curtis, Amalia, Gori, Andrea, Sighinolfi, Laura, Giacometti, Andrea, Capobianchi, Maria Rosaria, D'Avino, Alessandro, Iacoviello, Licia, Cauda, Roberto, D'Arminio Monforte, Antonella
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-HIV Agents - therapeutic use
Biological markers
Biomarkers - blood
Blood cholesterol
C-reactive protein
C-Reactive Protein - analysis
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - etiology
Care and treatment
Case-Control Studies
Diagnosis
Drug therapy
Female
Health aspects
Heart attacks
Highly active antiretroviral therapy
HIV
HIV Infections - blood
HIV Infections - complications
HIV Infections - drug therapy
HIV patients
Human immunodeficiency virus
Humans
Interleukin-6 - blood
Interleukins
Male
Middle Aged
Retrospective Studies
Risk Factors
Studies
Tissue plasminogen activator
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Summary:Elevated high-sensitivity C-reactive protein (hsCRP) increases the risk of cardiovascular disease (CVD) in the general population, but its role as a predictive marker in HIV-positive patients remains unclear. Aim of the study was to evaluate whether hsCRP or other biomarkers are independent predictors of CVD risk in HIV-infected patients. Retrospective, nested case-control study. HIV-positive men and women (35-69 years of age) receiving combination antiretroviral therapy (cART) were included. Cases (n = 35) had a major CVD event. Controls (n = 74) free from CVD events for at least 5 years from starting ART were matched on diabetes and smoking. HsCRP, D-dimer, P-selectin, interleukin-6 (IL-6), tissue plasminogen activator, plasminogen activator inhibitor-1 levels were measured. High hsCRP was associated with CVD risk, independently of traditional cardiovascular risk factors, HIV replication and the type of ART received at the time of sampling (adjusted odds ratio 8.00 [1.23-51.94] comparing >3.3 mg/L with
ISSN:1471-2334
1471-2334
DOI:10.1186/1471-2334-13-414