Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice

Systemic inflammation is correlated with dementia progression. Pro-inflammatory molecules can communicate from the periphery to the central nervous system to induce neuroinflammation and neurodegeneration. Our protein of interest is the pro-apoptotic kinase PKR (the double strand-RNA dependent prote...

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Bibliographic Details
Published in:Molecular neurodegeneration 2013-09, Vol.8 (Suppl 1), p.P32-P32
Main Authors: Mouton-Liger, François, Rebillat, Anne-Sophie, Pace, Clarisse, Gourmaud, Sarah, Taga, Mariko, Paquet, Claire, Hugon, Jacques
Format: Article
Language:English
Subjects:
Life Sciences
Neurobiology
Neurons and Cognition
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Summary:Systemic inflammation is correlated with dementia progression. Pro-inflammatory molecules can communicate from the periphery to the central nervous system to induce neuroinflammation and neurodegeneration. Our protein of interest is the pro-apoptotic kinase PKR (the double strand-RNA dependent protein kinase). Increased activated PKR levels were found in AD patients brain and cerebrospinal fluid. PKR activation can be triggered by inflammatory stresses and induces neurotoxicity in vitro. Is in vivo PKR-mediated inflammation involved in AD neurodegenerative process?
ISSN:1750-1326
1750-1326
DOI:10.1186/1750-1326-8-S1-P32