Alcoholism and liver disease in Mexico: genetic and environmental factors

Alcoholism and cirrhosis, which are two of the most serious health problems worldwide, have a broad spectrum of clinical outcomes. Both diseases are influenced by genetic susceptibility and cultural traits that differ globally but are specific for each population. In contrast to other regions around...

Full description

Saved in:
Bibliographic Details
Published in:World journal of gastroenterology : WJG 2013-11, Vol.19 (44), p.7972-7982
Main Authors: Roman, Sonia, Zepeda-Carrillo, Eloy Alfonso, Moreno-Luna, Laura Eugenia, Panduro, Arturo
Format: Article
Language:English
Subjects:
Alcohol Drinking - adverse effects
Alcohol Drinking - ethnology
Alcohol Drinking - genetics
Alcohol Drinking - mortality
Alcoholic Beverages
Alcoholism - ethnology
Alcoholism - genetics
Alcoholism - mortality
Cultural Characteristics
Gene-Environment Interaction
Genetic Predisposition to Disease
Heredity
Humans
Liver Diseases, Alcoholic - ethnology
Liver Diseases, Alcoholic - genetics
Liver Diseases, Alcoholic - mortality
Mexico - epidemiology
Pedigree
Prognosis
Review
Risk Factors
Social Behavior
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Alcoholism and cirrhosis, which are two of the most serious health problems worldwide, have a broad spectrum of clinical outcomes. Both diseases are influenced by genetic susceptibility and cultural traits that differ globally but are specific for each population. In contrast to other regions around the world, Mexicans present the highest drinking score and a high mortality rate for alcoholic liver disease with an intermediate category level of per capita alcohol consumption. Mexico has a unique history of alcohol consumption that is linked to profound anthropological and social aspects. The Mexican population has an admixture genome inherited from different races, Caucasian, Amerindian and African, with a heterogeneous distribution within the country. Thus, genes related to alcohol addiction, such as dopamine receptor D2 in the brain, or liver alcohol-metabolizing enzymes, such as alcohol dehydrogenase class I polypeptide B, cytochrome P450 2E1 and aldehyde dehydrogenase class 2, may vary from one individual to another. Furthermore, they may be inherited as risk or non-risk haplogroups that confer susceptibility or resistance either to alcohol addiction or abusive alcohol consumption and possibly liver disease. Thus, in this era of genomics, personalized medicine will benefit patients if it is directed according to individual or population-based data. Additional association studies will be required to establish novel strategies for the prevention, care and treatment of liver disease in Mexico and worldwide.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v19.i44.7972