Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese

• Published in: Toxicology (Amsterdam) 2013-12, Vol.314 (1), p.95-99
• Main Authors: Dinamene, Santos, Camila, Batoreu M, Tavares de Almeida, I, Davis Randall, L, Luisa, Mateus M, Vanda, Andrade, Ruben, Ramos, Edite, Torres, Michael, Aschner, Marreilha dos Santos, A.P
• Format: Article
• Language: English
• Subjects: Alterations; Animals; Behavior, Animal - drug effects; Brain; Brain - metabolism; Cerebral Cortex - chemistry; Cerebral Cortex - metabolism; Chlorides; Compartments; Dose-Response Relationship, Drug; Emergency; Endpoint Determination; Exposure; exposure duration; GFAP; Glial Fibrillary Acidic Protein - metabolism; Immunohistochemistry; Inflammation - chemically induced; Inflammation - pathology; Male; Manganese; Manganese - blood; Manganese - metabolism; Manganese - urine; Manganese Compounds; Manganese neurotoxicity; Manganese Poisoning - pathology; Manganese Poisoning - psychology; Motor Activity - drug effects; Neurobehavioral assays; Neuroinflammation; Parkinson disease; Rats; Rats, Wistar; rearing; Saline; Spectrophotometry, Atomic; TNF-α; toxicology; Urine
• ISSN: 0300-483X; 1879-3185
• DOI: 10.1016/j.tox.2013.09.008

Highlights • Whole blood (WB) and urine Mn are suitable indicators of brain Mn accumulation and exposure assessment. • WB and urine Mn levels are not suitable biomarkers of neuroinflammation. • Cortical neuroinflammation, and behavioral changes persist even after Mn is largely cleared from the brain. • Increased cortical GFAP-ir is persistent long-after Mn is cleared from the brain.