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Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese
Highlights • Whole blood (WB) and urine Mn are suitable indicators of brain Mn accumulation and exposure assessment. • WB and urine Mn levels are not suitable biomarkers of neuroinflammation. • Cortical neuroinflammation, and behavioral changes persist even after Mn is largely cleared from the brain...
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| Published in: | Toxicology (Amsterdam) 2013-12, Vol.314 (1), p.95-99 |
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| Main Authors: | , , , , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c596t-8589b2a55a8469e56f5fab02f353b31b061051aa7f5f984257c15e82a87d4c973 |
| container_end_page | 99 |
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| container_title | Toxicology (Amsterdam) |
| container_volume | 314 |
| creator | Dinamene, Santos Camila, Batoreu M Tavares de Almeida, I Davis Randall, L Luisa, Mateus M Vanda, Andrade Ruben, Ramos Edite, Torres Michael, Aschner Marreilha dos Santos, A.P |
| description | Highlights • Whole blood (WB) and urine Mn are suitable indicators of brain Mn accumulation and exposure assessment. • WB and urine Mn levels are not suitable biomarkers of neuroinflammation. • Cortical neuroinflammation, and behavioral changes persist even after Mn is largely cleared from the brain. • Increased cortical GFAP-ir is persistent long-after Mn is cleared from the brain. |
| doi_str_mv | 10.1016/j.tox.2013.09.008 |
| format | article |
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All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-8589b2a55a8469e56f5fab02f353b31b061051aa7f5f984257c15e82a87d4c973</citedby><cites>FETCH-LOGICAL-c596t-8589b2a55a8469e56f5fab02f353b31b061051aa7f5f984257c15e82a87d4c973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24060432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dinamene, Santos</creatorcontrib><creatorcontrib>Camila, Batoreu M</creatorcontrib><creatorcontrib>Tavares de Almeida, I</creatorcontrib><creatorcontrib>Davis Randall, L</creatorcontrib><creatorcontrib>Luisa, Mateus M</creatorcontrib><creatorcontrib>Vanda, Andrade</creatorcontrib><creatorcontrib>Ruben, Ramos</creatorcontrib><creatorcontrib>Edite, Torres</creatorcontrib><creatorcontrib>Michael, Aschner</creatorcontrib><creatorcontrib>Marreilha dos Santos, A.P</creatorcontrib><title>Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>Highlights • Whole blood (WB) and urine Mn are suitable indicators of brain Mn accumulation and exposure assessment. • WB and urine Mn levels are not suitable biomarkers of neuroinflammation. • Cortical neuroinflammation, and behavioral changes persist even after Mn is largely cleared from the brain. • Increased cortical GFAP-ir is persistent long-after Mn is cleared from the brain.</description><subject>Alterations</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Cerebral Cortex - chemistry</subject><subject>Cerebral Cortex - metabolism</subject><subject>Chlorides</subject><subject>Compartments</subject><subject>Dose-Response Relationship, Drug</subject><subject>Emergency</subject><subject>Endpoint Determination</subject><subject>Exposure</subject><subject>exposure duration</subject><subject>GFAP</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Immunohistochemistry</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - pathology</subject><subject>Male</subject><subject>Manganese</subject><subject>Manganese - blood</subject><subject>Manganese - metabolism</subject><subject>Manganese - urine</subject><subject>Manganese Compounds</subject><subject>Manganese neurotoxicity</subject><subject>Manganese Poisoning - pathology</subject><subject>Manganese Poisoning - psychology</subject><subject>Motor Activity - drug effects</subject><subject>Neurobehavioral assays</subject><subject>Neuroinflammation</subject><subject>Parkinson disease</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>rearing</subject><subject>Saline</subject><subject>Spectrophotometry, Atomic</subject><subject>TNF-α</subject><subject>toxicology</subject><subject>Urine</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkk1v1DAQhiMEoqXwA7hAjlyyjOM4cYRUCVXlQ6rEoVTqzZo4k10vib3Yzqp75o_jaEsFHBCnkWeedzTjd7LsJYMVA1a_3a6iu1uVwPgK2hWAfJSdMtm0BWdSPM5OgQMUleS3J9mzELYAUPKqfpqdlBXUUPHyNPtxucdxxmiczd2QW5q962iDe-M8jjna_pgzdhhxmjA6f8jJ9sUupWLIjc3jhvKdC7GguxRmn17kjeuXmsfEhLkrUM-RxiRdGOrz6PIJ7RotBXqePRlwDPTiPp5lNx8uv158Kq6-fPx88f6q0KKtYyGFbLsShUBZ1S2JehADdlAOXPCOsw5qBoIhNinfyqoUjWaCZImy6SvdNvwsOz_23c3dRL0mG9OOaufNhP6gHBr1Z8WajVq7veJSAGtkavDmvoF332cKUU0maBrHtIabg2J1DVDVkvP_QKsmsSCXsdgR1d6F4Gl4mIiBWnxWW5V8VovPClqVfE6aV7-v8qD4ZWwCXh-BAZ3CtTdB3VynDgKAVdA2kIh3R4LSl-8NeRW0IaupN550VL0z_xzg_C-1Ho01GsdvdKCwdbO3yUvFVCgVqOvlFJdLZCmWlbjlPwGMktpg</recordid><startdate>20131206</startdate><enddate>20131206</enddate><creator>Dinamene, Santos</creator><creator>Camila, Batoreu M</creator><creator>Tavares de Almeida, I</creator><creator>Davis Randall, L</creator><creator>Luisa, Mateus M</creator><creator>Vanda, Andrade</creator><creator>Ruben, Ramos</creator><creator>Edite, Torres</creator><creator>Michael, Aschner</creator><creator>Marreilha dos Santos, A.P</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope><scope>5PM</scope></search><sort><creationdate>20131206</creationdate><title>Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese</title><author>Dinamene, Santos ; Camila, Batoreu M ; Tavares de Almeida, I ; Davis Randall, L ; Luisa, Mateus M ; Vanda, Andrade ; Ruben, Ramos ; Edite, Torres ; Michael, Aschner ; Marreilha dos Santos, A.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-8589b2a55a8469e56f5fab02f353b31b061051aa7f5f984257c15e82a87d4c973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alterations</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Cerebral Cortex - chemistry</topic><topic>Cerebral Cortex - metabolism</topic><topic>Chlorides</topic><topic>Compartments</topic><topic>Dose-Response Relationship, Drug</topic><topic>Emergency</topic><topic>Endpoint Determination</topic><topic>Exposure</topic><topic>exposure duration</topic><topic>GFAP</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Immunohistochemistry</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - pathology</topic><topic>Male</topic><topic>Manganese</topic><topic>Manganese - blood</topic><topic>Manganese - metabolism</topic><topic>Manganese - urine</topic><topic>Manganese Compounds</topic><topic>Manganese neurotoxicity</topic><topic>Manganese Poisoning - pathology</topic><topic>Manganese Poisoning - psychology</topic><topic>Motor Activity - drug effects</topic><topic>Neurobehavioral assays</topic><topic>Neuroinflammation</topic><topic>Parkinson disease</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>rearing</topic><topic>Saline</topic><topic>Spectrophotometry, Atomic</topic><topic>TNF-α</topic><topic>toxicology</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dinamene, Santos</creatorcontrib><creatorcontrib>Camila, Batoreu M</creatorcontrib><creatorcontrib>Tavares de Almeida, I</creatorcontrib><creatorcontrib>Davis Randall, L</creatorcontrib><creatorcontrib>Luisa, Mateus M</creatorcontrib><creatorcontrib>Vanda, Andrade</creatorcontrib><creatorcontrib>Ruben, Ramos</creatorcontrib><creatorcontrib>Edite, Torres</creatorcontrib><creatorcontrib>Michael, Aschner</creatorcontrib><creatorcontrib>Marreilha dos Santos, A.P</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dinamene, Santos</au><au>Camila, Batoreu M</au><au>Tavares de Almeida, I</au><au>Davis Randall, L</au><au>Luisa, Mateus M</au><au>Vanda, Andrade</au><au>Ruben, Ramos</au><au>Edite, Torres</au><au>Michael, Aschner</au><au>Marreilha dos Santos, A.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>2013-12-06</date><risdate>2013</risdate><volume>314</volume><issue>1</issue><spage>95</spage><epage>99</epage><pages>95-99</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><abstract>Highlights • Whole blood (WB) and urine Mn are suitable indicators of brain Mn accumulation and exposure assessment. • WB and urine Mn levels are not suitable biomarkers of neuroinflammation. • Cortical neuroinflammation, and behavioral changes persist even after Mn is largely cleared from the brain. • Increased cortical GFAP-ir is persistent long-after Mn is cleared from the brain.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>24060432</pmid><doi>10.1016/j.tox.2013.09.008</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Toxicology (Amsterdam), 2013-12, Vol.314 (1), p.95-99 |
| issn | 0300-483X 1879-3185 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3850178 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Alterations Animals Behavior, Animal - drug effects Brain Brain - metabolism Cerebral Cortex - chemistry Cerebral Cortex - metabolism Chlorides Compartments Dose-Response Relationship, Drug Emergency Endpoint Determination Exposure exposure duration GFAP Glial Fibrillary Acidic Protein - metabolism Immunohistochemistry Inflammation - chemically induced Inflammation - pathology Male Manganese Manganese - blood Manganese - metabolism Manganese - urine Manganese Compounds Manganese neurotoxicity Manganese Poisoning - pathology Manganese Poisoning - psychology Motor Activity - drug effects Neurobehavioral assays Neuroinflammation Parkinson disease Rats Rats, Wistar rearing Saline Spectrophotometry, Atomic TNF-α toxicology Urine |
| title | Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese |
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