HLA-Association in patients with intolerance to mercury and other metals in dental materials

A group of selected 25 patients with serious intolerance to heavy metals used for dental restoration were examined for HLA antigens. A significant increase for HLA -- B37, B47 and DR4 was found. The value of the relative risk is not significant after correction for the number of antigens tested and...

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Bibliographic Details
Published in:Disease markers 2000, Vol.16 (3-4), p.135-138
Main Authors: PROCHAZKOVA, J, BARTOVA, J, IVASKOVA, E, KUPKOVA, L, STERZL, I, STEJSKAL, V. D. M
Format: Article
Language:English
Subjects:
Alloys - adverse effects
Biological and medical sciences
Dental Amalgam - adverse effects
Dental Materials - adverse effects
Drug Hypersensitivity - epidemiology
Drug Hypersensitivity - genetics
Ent and stomatology
Genetic Predisposition to Disease
HLA Antigens - genetics
HLA-B Antigens - genetics
HLA-B37 Antigen
HLA-DR4 Antigen - genetics
Humans
Medical sciences
Mercury - adverse effects
Metals, Heavy - adverse effects
Other
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Risk
Stomatology
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Summary:A group of selected 25 patients with serious intolerance to heavy metals used for dental restoration were examined for HLA antigens. A significant increase for HLA -- B37, B47 and DR4 was found. The value of the relative risk is not significant after correction for the number of antigens tested and therefore further studies of more patients are needed.
ISSN:0278-0240
1875-8630
DOI:10.1155/2000/205757