Tigecycline treatment of infection caused by KPC-producing Escherichia coli in a pediatric patient

Tigecycline shows great antimicrobial activity against both Gram-positive and Gram-negative bacteria, and has been considered to be an appropriate choice in controlling infection caused by multi-drug resistant (MDR) pathogens, such as carbapenemase-producing Enterobacteriaceae (CPE). Although many c...

Full description

Saved in:
Bibliographic Details
Published in:Annals of clinical microbiology and antimicrobials 2013-08, Vol.12 (1), p.19-19, Article 19
Main Authors: Du, Xiaoxing, Fu, Ying, Yu, Yunsong
Format: Article
Language:English
Subjects:
Abdomen
Adolescent
Analysis
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Antimicrobial agents
Bacteria
Bacterial Proteins - metabolism
Beta lactamases
beta-Lactamases - metabolism
Care and treatment
Case Report
Case studies
Consent
Diagnosis
Drug resistance
Drug Resistance, Multiple, Bacterial
E coli
Escherichia coli - enzymology
Escherichia coli Infections - drug therapy
Humans
Infections
Klebsiella infections
Klebsiella pneumoniae - enzymology
Male
Medical colleges
Medical research
Medicine, Experimental
Microbial Sensitivity Tests
Minocycline - adverse effects
Minocycline - analogs & derivatives
Minocycline - therapeutic use
Mortality
Pain
Side effects
Tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tigecycline shows great antimicrobial activity against both Gram-positive and Gram-negative bacteria, and has been considered to be an appropriate choice in controlling infection caused by multi-drug resistant (MDR) pathogens, such as carbapenemase-producing Enterobacteriaceae (CPE). Although many clinical trials evaluate the efficacy and safety of tigecycline on adults, rare reports recommend tigecycline to treat pediatric patient. In this study, we presented a clinical case with tigecycline as an anti-infectious agent on a 14-year-old child who was suffering from infection of intraperitoneal abscess caused by Klebsiella pneumoniae carbapenemases (KPC)-producing Escherichia coli with extreme drug resistant profile. By accessing the clinical outcome and efficacy of the patient, and the side effects of tigecycline, our research explored the documented experience of tigecycline on controlling infection caused by CPE isolate in children.
ISSN:1476-0711
1476-0711
DOI:10.1186/1476-0711-12-19