Microbiota impact on the epigenetic regulation of colorectal cancer

Highlights • We examine the role of the intestinal microbiota in colorectal cancer. • We thoroughly discuss the epigenetic regulation of colorectal carcinogenesis. • We propose the use of engineered bacteria to rebalance inflammation in the gut.

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Bibliographic Details
Published in:Trends in molecular medicine 2013-12, Vol.19 (12), p.714-725
Main Authors: Yang, Tao, Owen, Jennifer L, Lightfoot, Yaíma L, Kladde, Michael P, Mohamadzadeh, Mansour
Format: Article
Language:English
Subjects:
Animals
Bacteria - genetics
Bacteria - immunology
colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - immunology
Colorectal Neoplasms - microbiology
commensal bacteria
Epigenesis, Genetic
epigenetic regulation
Gastrointestinal Tract - microbiology
Humans
inflammatory bowel disease
Microbiota
Pathology
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Description
Summary:Highlights • We examine the role of the intestinal microbiota in colorectal cancer. • We thoroughly discuss the epigenetic regulation of colorectal carcinogenesis. • We propose the use of engineered bacteria to rebalance inflammation in the gut.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2013.08.005