Transformation of Physical DVHs to Radiobiologically Equivalent Ones in Hypofractionated Radiotherapy Analyzing Dosimetric and Clinical Parameters : A Practical Approach for Routine Clinical Practice in Radiation Oncology

Purpose. The purpose of this study was to transform DVHs from physical to radiobiological ones as well as to evaluate their reliability by correlations of dosimetric and clinical parameters for 50 patients with prostate cancer and 50 patients with breast cancer, who were submitted to Hypofractionate...

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Published in:Computational and mathematical methods in medicine 2013-01, Vol.2013 (2013), p.1-8
Main Authors: Thrapsanioti, Zoi, Karanasiou, Irene, Platoni, Kalliopi, Efstathopoulos, Efstathios P., Matsopoulos, George, Dilvoi, Maria, Patatoukas, George, Chaldeopoulos, Demetrios, Kelekis, Nikolaos, Kouloulias, Vassilis
Format: Article
Language:English
Subjects:
Aged
Algorithms
Breast Neoplasms - radiotherapy
Dose Fractionation
Female
Humans
Linear Models
Male
Middle Aged
Prostatic Neoplasms - radiotherapy
Radiometry - methods
Radiotherapy - methods
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Reproducibility of Results
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Summary:Purpose. The purpose of this study was to transform DVHs from physical to radiobiological ones as well as to evaluate their reliability by correlations of dosimetric and clinical parameters for 50 patients with prostate cancer and 50 patients with breast cancer, who were submitted to Hypofractionated Radiotherapy. Methods and Materials. To achieve this transformation, we used both the linear-quadratic model (LQ model) and the Niemierko model. The outcome of radiobiological DVHs was correlated with acute toxicity score according to EORTC/RTOG criteria. Results. Concerning the prostate radiotherapy, there was a significant correlation between RTOG acute rectal toxicity and D50 (P
ISSN:1748-670X
1748-6718
DOI:10.1155/2013/713420