SOD2 gene Val16Ala polymorphism is associated with macroalbuminuria in Mexican type 2 diabetes patients: a comparative study and meta-analysis

Several studies in type 2 diabetes patients have shown significant associations between the SOD2 gene Val16Ala polymorphism and albuminuria, but this association has not been explored in the Mexican population. We evaluated the association between the SOD2 gene Val16Ala polymorphism (rs4880) and mac...

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Bibliographic Details
Published in:BMC medical genetics 2013-10, Vol.14 (1), p.110-110
Main Authors: Ascencio-Montiel, Iván de Jesús, Parra, Esteban J, Valladares-Salgado, Adán, Gómez-Zamudio, Jaime H, Kumate-Rodriguez, Jesús, Escobedo-de-la-Peña, Jorge, Cruz, Miguel
Format: Article
Language:English
Subjects:
Aged
Albuminuria - complications
Albuminuria - genetics
Alleles
Body mass index
Cholesterol
Confidence intervals
Deoxyribonucleic acid
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - genetics
DNA
Enzymes
Epidemiology
Female
Gene Frequency
Genealogy
Genomes
Genotype
Hospitals
Humans
Hypertension
Logistic Models
Male
Mexico - ethnology
Middle Aged
Mortality
Odds Ratio
Oxidative stress
Pathogenesis
Polymorphism, Single Nucleotide
Population
Rodents
Smoking
Studies
Superoxide Dismutase - genetics
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Summary:Several studies in type 2 diabetes patients have shown significant associations between the SOD2 gene Val16Ala polymorphism and albuminuria, but this association has not been explored in the Mexican population. We evaluated the association between the SOD2 gene Val16Ala polymorphism (rs4880) and macroalbuminuria in a sample of 994 unrelated Mexican type 2 diabetes patients. The study included 119 subjects with urinary albumin >300 mg/dL and 875 subjects with urinary albumin ≤ 30 mg/dL. Genotyping of the SOD2 gene Val16Ala SNP was carried out with Real-Time Polymerase Chain Reaction (RT-PCR). The frequency of the TT genotype was 6.7% higher in participants with macroalbuminuria than in the normoalbuminuria group (16.8% vs. 10.1%). Using a logistic regression analysis, we observed that individuals with the CC genotype had significantly lower risks of macroalbuminuria than those with the TT genotype (OR=0.42, p=0.034). We carried out a meta-analysis combining our data with data from four previous studies and estimated an odds ratio (95% CI) for the C allele (with respect to the reference T allele) of 0.65 (0.52-0.80, p
ISSN:1471-2350
1471-2350
DOI:10.1186/1471-2350-14-110