Is the Observed Association Between Dairy Intake and Fibroids in African Americans Explained by Genetic Ancestry?

Uterine leiomyomata are a major source of gynecological morbidity and are 2-3 times more prevalent in African Americans than European Americans. In an earlier report, we found that dairy intake was inversely associated with uterine leiomyomata among African Americans. Because African Americans are m...

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Bibliographic Details
Published in:American journal of epidemiology 2013-10, Vol.178 (7), p.1114-1119
Main Authors: WISE, Lauren A, PALMER, Julie R, RUIZ-NARVAEZ, Edward, REICH, David E, ROSENBERG, Lynn
Format: Article
Language:English
Subjects:
Adult
African Americans
Biological and medical sciences
Dairy products
Dairy Products - statistics & numerical data
Epidemiology
Female
Genealogy
General aspects
Genetic Predisposition to Disease
Gynecology
Humans
Leiomyoma - ethnology
Leiomyoma - genetics
Medical sciences
Middle Aged
Miscellaneous
Morbidity
Original Contributions
Prevalence
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Tumors
United States - ethnology
Uterine Neoplasms - ethnology
Uterine Neoplasms - genetics
Womens health
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Summary:Uterine leiomyomata are a major source of gynecological morbidity and are 2-3 times more prevalent in African Americans than European Americans. In an earlier report, we found that dairy intake was inversely associated with uterine leiomyomata among African Americans. Because African Americans are more likely to have lactose intolerance and avoid dairy products, the observed association might have been confounded by genetic ancestry. This report reevaluates the dairy-uterine leiomyomata association after accounting for genetic ancestry among 1,968 cases and 2,183 noncases from the Black Women's Health Study (1997-2007). Dairy intake was estimated by using food frequency questionnaires in 1995 and 2001. Percent European ancestry was estimated by using a panel of ancestry informative markers. Incidence rate ratios and 95% confidence intervals were estimated by using Cox regression, with adjustment for potential confounders and percent European ancestry. Incidence rate ratios comparing 1, 2, 3, and ≥4 servings/day with
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwt091