Lineage relationship of effector and memory T cells

Adaptive immunity is characterized by the ability to form long-lived immunological memory. Upon re-exposure to antigen, memory T cells respond more rapidly and robustly than naïve T cells, providing better clearance of pathogens. Recent reviews have reinforced the text-book view that memory T cells...

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Bibliographic Details
Published in:Current opinion in immunology 2013-10, Vol.25 (5), p.556-563
Main Authors: Restifo, Nicholas P, Gattinoni, Luca
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Cell Lineage
Humans
Immunity, Innate
Immunologic Memory
Models, Immunological
T-Lymphocytes - cytology
T-Lymphocytes - immunology
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Summary:Adaptive immunity is characterized by the ability to form long-lived immunological memory. Upon re-exposure to antigen, memory T cells respond more rapidly and robustly than naïve T cells, providing better clearance of pathogens. Recent reviews have reinforced the text-book view that memory T cells arise from effector cells. Although this notion is teleologically appealing, emerging data are more consistent with a model where naïve cells directly develop into memory cells without transitioning through an effector stage. A clear understanding of the lineage relationships between memory and effector cells has profound implications for the design of vaccines and for the development of effective T cell-based therapies.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2013.09.003