Dysregulation in myelination mediated by persistent neuroinflammation: Possible mechanisms in chemotherapy-related cognitive impairment

Highlight • Our study shows proof of concept that myelin changes mediated by neuroinflammation is a possible mechanism in chemotherapy-induced cognitive deficit.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2014-01, Vol.35, p.23-32
Main Authors: Briones, Teresita L, Woods, Julie
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antineoplastic Combined Chemotherapy Protocols - toxicity
Cognition Disorders - chemically induced
Cognition Disorders - immunology
Cognition Disorders - pathology
Corpus callosum
Corpus Callosum - ultrastructure
COX-2
Cyclophosphamide - administration & dosage
Cyclophosphamide - toxicity
Cytokines - metabolism
Female
Fluorouracil - administration & dosage
Fluorouracil - toxicity
IL-10
IL-1beta
Inflammation - chemically induced
Inflammation - metabolism
Methotrexate - administration & dosage
Methotrexate - toxicity
Nerve Fibers, Myelinated - ultrastructure
Psychiatry
Random Allocation
Rats
Rats, Sprague-Dawley
Recognition (Psychology) - drug effects
TNF-alpha
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Description
Summary:Highlight • Our study shows proof of concept that myelin changes mediated by neuroinflammation is a possible mechanism in chemotherapy-induced cognitive deficit.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2013.07.175