Altered Peptidase Activities in Thyroid Neoplasia and Hyperplasia

Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26) in the development of thyroid neoplasia and proposed it a...

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Bibliographic Details
Published in:Disease markers 2013-01, Vol.2013 (2013), p.1-8
Main Authors: Andrés, Leire, López, José I., Santaolalla, Francisco, Irazusta, Amaia, Perez, Itxaro, Sanz, Begoña, Beitia, Maider, Errarte, Peio, Blanco, Lorena, Larrinaga, Gorka, Sánchez, Clara E.
Format: Article
Language:English
Subjects:
Adenocarcinoma, Follicular - enzymology
Adult
Carcinoma, Papillary - enzymology
CD13 Antigens - metabolism
Dipeptidyl Peptidase 4 - metabolism
Female
Glutamyl Aminopeptidase - metabolism
Humans
Hyperplasia - enzymology
Male
Middle Aged
Pyroglutamyl-Peptidase I - metabolism
Serine Endopeptidases - metabolism
Thyroid Gland - enzymology
Thyroid Gland - pathology
Thyroid Neoplasms - enzymology
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Summary:Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26) in the development of thyroid neoplasia and proposed it as an additional tool in the diagnosis/prognosis of these diseases. However, very little is known about the involvement of other peptidases in neoplastic and hyperplastic processes of this gland. Methods. The catalytic activity of 10 peptidases in a series of 30 PTC, 10 FTA, and 14 TNH was measured fluorimetrically in tumour and nontumour adjacent tissues. Results. The activity of DPPIV/CD26 was markedly higher in PTC than in FTA, TNH, and nontumour tissues. Aspartyl aminopeptidase (AspAP), alanyl aminopeptidase (AlaAP), prolyl endopeptidase, pyroglutamyl peptidase I, and aminopeptidase B activities were significantly increased in thyroid neoplasms when compared to nontumour tissues. AspAP and AlaAP activities were also significantly higher in PTC than in FTA and TNH. Conclusions. These data suggest the involvement of DPPIV/CD26 and some cytosolic peptidases in the neoplastic development of PTC and FTA. Further studies will help to define the possible clinical usefulness of AlaAP and AspAP in the diagnosis/prognosis of thyroid neoplasms.
ISSN:0278-0240
1875-8630
DOI:10.1155/2013/970736