Montelukast and emotional well-being as a marker for depression: Results from 3 randomized, double-masked clinical trials

[...]we reviewed 3 randomized, double-masked, controlled trials conducted by the American Lung Association Asthma Clinical Research Centers (ALA-ACRC) that included montelukast as a treatment assignment to determine whether there was any signal suggesting an effect of montelukast on emotional well-b...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2008-10, Vol.122 (4), p.828-829
Main Authors: Holbrook, Janet T., PhD, MPH, Harik-Khan, Raida, PhD
Format: Article
Language:English
Subjects:
Acetates - administration & dosage
Acetates - adverse effects
Adult
Age
Allergy and Immunology
Anti-Asthmatic Agents - administration & dosage
Anti-Asthmatic Agents - adverse effects
Asthma
Asthma - drug therapy
Asthma - psychology
Clinical trials
Cyclopropanes
Depression - chemically induced
Depression - psychology
Double-Blind Method
Emotions - drug effects
Female
Humans
Male
Multicenter Studies as Topic
Quality of Life
Questionnaires
Quinolines - administration & dosage
Quinolines - adverse effects
Randomized Controlled Trials as Topic
Suicide
Sulfides
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Summary:[...]we reviewed 3 randomized, double-masked, controlled trials conducted by the American Lung Association Asthma Clinical Research Centers (ALA-ACRC) that included montelukast as a treatment assignment to determine whether there was any signal suggesting an effect of montelukast on emotional well-being.2,3 A total of 1469 patients were enrolled. [...]we did not find evidence of a negative effect of montelukast on emotional well being in any of the 3 ACRC trials.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2008.07.012