Osteonecrosis of the jaw related to everolimus and bisphosphonate: a unique case report?

Osteonecrosis of the jaw (ONJ) is a rare but serious lesion of the jaw, characterized mainly by exposed necrotic bone; it is related to various drugs, usually used for treating patients with advanced malignancies. Drugs implicated in ONJ are: nitrogen-containing bisphosphonates (NBP), denosumab, ant...

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Bibliographic Details
Published in:Annali di stomatologia 2013, Vol.4 (Suppl 2), p.20-21
Main Authors: Giancola, F, Campisi, G, Lo Russo, L, Muzio, L Lo, Di Fede, O
Format: Article
Language:English
Subjects:
Breast cancer
Case Report
Medical research
Online Access:Get full text
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Summary:Osteonecrosis of the jaw (ONJ) is a rare but serious lesion of the jaw, characterized mainly by exposed necrotic bone; it is related to various drugs, usually used for treating patients with advanced malignancies. Drugs implicated in ONJ are: nitrogen-containing bisphosphonates (NBP), denosumab, anti-angiogenic drugs and the selective mammalian target of rapamycin mTOR, everolimus. Previous data regarding the combining of NBPs with antiangiogenic agents conflict with some reports; other reports show significantly higher rates of the incidence of ONJ^sup 2^.
ISSN:1824-0852
1971-1441