Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders

MicroRNAs (miRNAs) are members of a large class of non-protein-coding RNA (ncRNA) molecules that represent a significant, but until recently unappreciated, layer of cellular regulation. Assessment of the generation and function of miRNAs suggests that these ncRNAs are vulnerable to interference from...

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Bibliographic Details
Published in:Alcohol research 2013-03, Vol.35 (1), p.18-24
Main Authors: Balaraman, Sridevi, Tingling, Joseph D, Tsai, Pai-Chi, Miranda, Rajesh C
Format: Article
Language:English
Subjects:
Analysis
Animal cognition
Brain research
Causes and theories of causation
Causes of
Cell regulation
Cellular control mechanisms
Central Nervous System Depressants - adverse effects
Diseases
DNA methylation
Effect of alcohol on
Epigenetic inheritance
Epigenetics
Ethanol
Ethanol - adverse effects
Etiology (Medicine)
Female
Fetal Alcohol Spectrum Disorders - genetics
Fetal alcohol syndrome
Fetal development
Fetus
Fetuses
Gene Expression
Gene Expression Regulation - drug effects
Genetic aspects
Growth
Health aspects
Humans
Metabolic disorders
MicroRNA
MicroRNAs
Nicotine
Pregnancy
Proteins
Studies
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Summary:MicroRNAs (miRNAs) are members of a large class of non-protein-coding RNA (ncRNA) molecules that represent a significant, but until recently unappreciated, layer of cellular regulation. Assessment of the generation and function of miRNAs suggests that these ncRNAs are vulnerable to interference from genetic, epigenetic, and environmental factors. A small but rapidly expanding body of studies using a variety of animal- and cell culture-based experimental models also has shown that miRNAs are important targets of alcohol during fetal development and that their dysregulation likely plays a significant role in the etiology of fetal alcohol spectrum disorders (FASD). Accordingly, an analysis of the regulation and function of these miRNAs may yield important clues to the management of FASD.
ISSN:2168-3492
2169-4796