Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders

MicroRNAs (miRNAs) are members of a large class of non-protein-coding RNA (ncRNA) molecules that represent a significant, but until recently unappreciated, layer of cellular regulation. Assessment of the generation and function of miRNAs suggests that these ncRNAs are vulnerable to interference from...

Full description

Saved in:
Bibliographic Details
Published in:Alcohol research 2013-03, Vol.35 (1), p.18-24
Main Authors: Balaraman, Sridevi, Tingling, Joseph D, Tsai, Pai-Chi, Miranda, Rajesh C
Format: Article
Language:English
Subjects:
Analysis
Animal cognition
Brain research
Causes and theories of causation
Causes of
Cell regulation
Cellular control mechanisms
Central Nervous System Depressants - adverse effects
Diseases
DNA methylation
Effect of alcohol on
Epigenetic inheritance
Epigenetics
Ethanol
Ethanol - adverse effects
Etiology (Medicine)
Female
Fetal Alcohol Spectrum Disorders - genetics
Fetal alcohol syndrome
Fetal development
Fetus
Fetuses
Gene Expression
Gene Expression Regulation - drug effects
Genetic aspects
Growth
Health aspects
Humans
Metabolic disorders
MicroRNA
MicroRNAs
Nicotine
Pregnancy
Proteins
Studies
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 24
container_issue 1
container_start_page 18
container_title Alcohol research
container_volume 35
creator Balaraman, Sridevi
Tingling, Joseph D
Tsai, Pai-Chi
Miranda, Rajesh C
description MicroRNAs (miRNAs) are members of a large class of non-protein-coding RNA (ncRNA) molecules that represent a significant, but until recently unappreciated, layer of cellular regulation. Assessment of the generation and function of miRNAs suggests that these ncRNAs are vulnerable to interference from genetic, epigenetic, and environmental factors. A small but rapidly expanding body of studies using a variety of animal- and cell culture-based experimental models also has shown that miRNAs are important targets of alcohol during fetal development and that their dysregulation likely plays a significant role in the etiology of fetal alcohol spectrum disorders (FASD). Accordingly, an analysis of the regulation and function of these miRNAs may yield important clues to the management of FASD.
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3860419</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A347522729</galeid><sourcerecordid>A347522729</sourcerecordid><originalsourceid>FETCH-LOGICAL-g401t-82d4e55e4188c16d13deb5cf522d6de0082cf8b870c252d4903a877a2f40b8883</originalsourceid><addsrcrecordid>eNp9kk2LFDEQhhtR3GXdvyABTx5aOh_dSV-EYXRXYXBB9BzSSXVPlnQym6Rl59-bWcePgcHkkFD11JuXqjyrLgnu-prxvnv-dBc1ZT25qK5Tum_K4rxnHX1ZXRBGMcUdvqwePuxThGlxKtvgURjRbHUMX7-sEDzuIqR0CCtv0Lh4_cTo4HO0w5IhoRxQ3gKCknBh2h_qR8jKIeV02AaH0g50jsuMjE0hGojpVfViVC7B9fG8qr7ffPy2_lRv7m4_r1ebemINzrUghkHbAsNCaNwZTA0MrR5bQkxnoGkE0aMYBG80aQvbN1QJzhUZWTMIIehV9f6X7m4ZZjAaimvl5C7aWcW9DMrK04y3WzmFH5KKrmG4LwJvjgIxPCyQsrwPS_TFs8SMUs656NhfalIOpPVjKGJ6tknLFWW82OXkoFWfoSbwUF4OHkZbwif8uzN82QbKfM4WvD0pOAwJHvOklpSkuN38z8yR1cE5mECWKazvTvnX_3byTwt__yL6E0Lkw-Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1433777864</pqid></control><display><type>article</type><title>Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders</title><source>Criminology Collection</source><source>NCBI_PubMed Central（免费）</source><source>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</source><creator>Balaraman, Sridevi ; Tingling, Joseph D ; Tsai, Pai-Chi ; Miranda, Rajesh C</creator><creatorcontrib>Balaraman, Sridevi ; Tingling, Joseph D ; Tsai, Pai-Chi ; Miranda, Rajesh C</creatorcontrib><description>MicroRNAs (miRNAs) are members of a large class of non-protein-coding RNA (ncRNA) molecules that represent a significant, but until recently unappreciated, layer of cellular regulation. Assessment of the generation and function of miRNAs suggests that these ncRNAs are vulnerable to interference from genetic, epigenetic, and environmental factors. A small but rapidly expanding body of studies using a variety of animal- and cell culture-based experimental models also has shown that miRNAs are important targets of alcohol during fetal development and that their dysregulation likely plays a significant role in the etiology of fetal alcohol spectrum disorders (FASD). Accordingly, an analysis of the regulation and function of these miRNAs may yield important clues to the management of FASD.</description><identifier>ISSN: 2168-3492</identifier><identifier>EISSN: 2169-4796</identifier><identifier>PMID: 24313161</identifier><language>eng</language><publisher>United States: U.S. Government Printing Office</publisher><subject>Analysis ; Animal cognition ; Brain research ; Causes and theories of causation ; Causes of ; Cell regulation ; Cellular control mechanisms ; Central Nervous System Depressants - adverse effects ; Diseases ; DNA methylation ; Effect of alcohol on ; Epigenetic inheritance ; Epigenetics ; Ethanol ; Ethanol - adverse effects ; Etiology (Medicine) ; Female ; Fetal Alcohol Spectrum Disorders - genetics ; Fetal alcohol syndrome ; Fetal development ; Fetus ; Fetuses ; Gene Expression ; Gene Expression Regulation - drug effects ; Genetic aspects ; Growth ; Health aspects ; Humans ; Metabolic disorders ; MicroRNA ; MicroRNAs ; Nicotine ; Pregnancy ; Proteins ; Studies</subject><ispartof>Alcohol research, 2013-03, Vol.35 (1), p.18-24</ispartof><rights>COPYRIGHT 2013 U.S. Government Printing Office</rights><rights>COPYRIGHT 2013 U.S. Government Printing Office</rights><rights>Copyright Superintendent of Documents 2013</rights><rights>2013</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860419/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860419/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24313161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balaraman, Sridevi</creatorcontrib><creatorcontrib>Tingling, Joseph D</creatorcontrib><creatorcontrib>Tsai, Pai-Chi</creatorcontrib><creatorcontrib>Miranda, Rajesh C</creatorcontrib><title>Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders</title><title>Alcohol research</title><addtitle>Alcohol Res</addtitle><description>MicroRNAs (miRNAs) are members of a large class of non-protein-coding RNA (ncRNA) molecules that represent a significant, but until recently unappreciated, layer of cellular regulation. Assessment of the generation and function of miRNAs suggests that these ncRNAs are vulnerable to interference from genetic, epigenetic, and environmental factors. A small but rapidly expanding body of studies using a variety of animal- and cell culture-based experimental models also has shown that miRNAs are important targets of alcohol during fetal development and that their dysregulation likely plays a significant role in the etiology of fetal alcohol spectrum disorders (FASD). Accordingly, an analysis of the regulation and function of these miRNAs may yield important clues to the management of FASD.</description><subject>Analysis</subject><subject>Animal cognition</subject><subject>Brain research</subject><subject>Causes and theories of causation</subject><subject>Causes of</subject><subject>Cell regulation</subject><subject>Cellular control mechanisms</subject><subject>Central Nervous System Depressants - adverse effects</subject><subject>Diseases</subject><subject>DNA methylation</subject><subject>Effect of alcohol on</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Ethanol</subject><subject>Ethanol - adverse effects</subject><subject>Etiology (Medicine)</subject><subject>Female</subject><subject>Fetal Alcohol Spectrum Disorders - genetics</subject><subject>Fetal alcohol syndrome</subject><subject>Fetal development</subject><subject>Fetus</subject><subject>Fetuses</subject><subject>Gene Expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genetic aspects</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Metabolic disorders</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>Nicotine</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Studies</subject><issn>2168-3492</issn><issn>2169-4796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ALSLI</sourceid><sourceid>BGRYB</sourceid><sourceid>M0O</sourceid><sourceid>M2R</sourceid><recordid>eNp9kk2LFDEQhhtR3GXdvyABTx5aOh_dSV-EYXRXYXBB9BzSSXVPlnQym6Rl59-bWcePgcHkkFD11JuXqjyrLgnu-prxvnv-dBc1ZT25qK5Tum_K4rxnHX1ZXRBGMcUdvqwePuxThGlxKtvgURjRbHUMX7-sEDzuIqR0CCtv0Lh4_cTo4HO0w5IhoRxQ3gKCknBh2h_qR8jKIeV02AaH0g50jsuMjE0hGojpVfViVC7B9fG8qr7ffPy2_lRv7m4_r1ebemINzrUghkHbAsNCaNwZTA0MrR5bQkxnoGkE0aMYBG80aQvbN1QJzhUZWTMIIehV9f6X7m4ZZjAaimvl5C7aWcW9DMrK04y3WzmFH5KKrmG4LwJvjgIxPCyQsrwPS_TFs8SMUs656NhfalIOpPVjKGJ6tknLFWW82OXkoFWfoSbwUF4OHkZbwif8uzN82QbKfM4WvD0pOAwJHvOklpSkuN38z8yR1cE5mECWKazvTvnX_3byTwt__yL6E0Lkw-Q</recordid><startdate>20130322</startdate><enddate>20130322</enddate><creator>Balaraman, Sridevi</creator><creator>Tingling, Joseph D</creator><creator>Tsai, Pai-Chi</creator><creator>Miranda, Rajesh C</creator><general>U.S. Government Printing Office</general><general>Superintendent of Documents</general><general>National Institute on Alcohol Abuse and Alcoholism</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8GL</scope><scope>0-V</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>88J</scope><scope>8AF</scope><scope>8AM</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K7.</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0O</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M2R</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>5PM</scope></search><sort><creationdate>20130322</creationdate><title>Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders</title><author>Balaraman, Sridevi ; Tingling, Joseph D ; Tsai, Pai-Chi ; Miranda, Rajesh C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g401t-82d4e55e4188c16d13deb5cf522d6de0082cf8b870c252d4903a877a2f40b8883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analysis</topic><topic>Animal cognition</topic><topic>Brain research</topic><topic>Causes and theories of causation</topic><topic>Causes of</topic><topic>Cell regulation</topic><topic>Cellular control mechanisms</topic><topic>Central Nervous System Depressants - adverse effects</topic><topic>Diseases</topic><topic>DNA methylation</topic><topic>Effect of alcohol on</topic><topic>Epigenetic inheritance</topic><topic>Epigenetics</topic><topic>Ethanol</topic><topic>Ethanol - adverse effects</topic><topic>Etiology (Medicine)</topic><topic>Female</topic><topic>Fetal Alcohol Spectrum Disorders - genetics</topic><topic>Fetal alcohol syndrome</topic><topic>Fetal development</topic><topic>Fetus</topic><topic>Fetuses</topic><topic>Gene Expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Genetic aspects</topic><topic>Growth</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Metabolic disorders</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>Nicotine</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>Balaraman, Sridevi</creatorcontrib><creatorcontrib>Tingling, Joseph D</creatorcontrib><creatorcontrib>Tsai, Pai-Chi</creatorcontrib><creatorcontrib>Miranda, Rajesh C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Gale In Context: High School</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing &amp; Allied Health Database</collection><collection>ProQuest_Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Criminology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Criminal Justice Database</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>ProQuest_Research Library</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Social Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alcohol research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balaraman, Sridevi</au><au>Tingling, Joseph D</au><au>Tsai, Pai-Chi</au><au>Miranda, Rajesh C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders</atitle><jtitle>Alcohol research</jtitle><addtitle>Alcohol Res</addtitle><date>2013-03-22</date><risdate>2013</risdate><volume>35</volume><issue>1</issue><spage>18</spage><epage>24</epage><pages>18-24</pages><issn>2168-3492</issn><eissn>2169-4796</eissn><abstract>MicroRNAs (miRNAs) are members of a large class of non-protein-coding RNA (ncRNA) molecules that represent a significant, but until recently unappreciated, layer of cellular regulation. Assessment of the generation and function of miRNAs suggests that these ncRNAs are vulnerable to interference from genetic, epigenetic, and environmental factors. A small but rapidly expanding body of studies using a variety of animal- and cell culture-based experimental models also has shown that miRNAs are important targets of alcohol during fetal development and that their dysregulation likely plays a significant role in the etiology of fetal alcohol spectrum disorders (FASD). Accordingly, an analysis of the regulation and function of these miRNAs may yield important clues to the management of FASD.</abstract><cop>United States</cop><pub>U.S. Government Printing Office</pub><pmid>24313161</pmid><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2168-3492
ispartof Alcohol research, 2013-03, Vol.35 (1), p.18-24
issn 2168-3492
2169-4796
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3860419
source Criminology Collection; NCBI_PubMed Central（免费）; Social Science Premium Collection (Proquest) (PQ_SDU_P3)
subjects Analysis
Animal cognition
Brain research
Causes and theories of causation
Causes of
Cell regulation
Cellular control mechanisms
Central Nervous System Depressants - adverse effects
Diseases
DNA methylation
Effect of alcohol on
Epigenetic inheritance
Epigenetics
Ethanol
Ethanol - adverse effects
Etiology (Medicine)
Female
Fetal Alcohol Spectrum Disorders - genetics
Fetal alcohol syndrome
Fetal development
Fetus
Fetuses
Gene Expression
Gene Expression Regulation - drug effects
Genetic aspects
Growth
Health aspects
Humans
Metabolic disorders
MicroRNA
MicroRNAs
Nicotine
Pregnancy
Proteins
Studies
title Dysregulation of microRNA expression and function contributes to the etiology of fetal alcohol spectrum disorders
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T03%3A14%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dysregulation%20of%20microRNA%20expression%20and%20function%20contributes%20to%20the%20etiology%20of%20fetal%20alcohol%20spectrum%20disorders&rft.jtitle=Alcohol%20research&rft.au=Balaraman,%20Sridevi&rft.date=2013-03-22&rft.volume=35&rft.issue=1&rft.spage=18&rft.epage=24&rft.pages=18-24&rft.issn=2168-3492&rft.eissn=2169-4796&rft_id=info:doi/&rft_dat=%3Cgale_pubme%3EA347522729%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-g401t-82d4e55e4188c16d13deb5cf522d6de0082cf8b870c252d4903a877a2f40b8883%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1433777864&rft_id=info:pmid/24313161&rft_galeid=A347522729&rfr_iscdi=true