Effect of spironolactone on ventricular arrhythmias in patients with left ventricular systolic dysfunction and implantable cardioverter defibrillators

Abstract Aims/objectives Patients with implantable cardioverter defibrillators (ICD) often receive an adjunctive anti-arrhythmic therapy. We propose that an addition of spironolactone will reduce the number of clinically significant ventricular arrhythmias and ICD-related therapies. Methods and resu...

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Bibliographic Details
Published in:Indian heart journal 2012-03, Vol.64 (2), p.123-127
Main Authors: Wase, Abdul, Garikipati, Naga, Mufti, Omar, Mirza, Zulfiqar, Innaparthy, Aparna, Kabir, Anwarul, Quraishi, Mohammed B, Markert, Ronald
Format: Article
Language:English
Subjects:
Aged
Aldosterone antagonists ICD shocks
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - prevention & control
Cardiovascular
Defibrillators, Implantable
Female
Heart Failure - complications
Heart Failure - therapy
Humans
Implantable cardioverter defibrillators (ICDs)
Male
Middle Aged
Mineralocorticoid Receptor Antagonists - pharmacology
Original
Retrospective Studies
Spironolactone - pharmacology
Spironolactone Ventricular tachycardia (VT)
Ventricular Dysfunction, Left - complications
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Summary:Abstract Aims/objectives Patients with implantable cardioverter defibrillators (ICD) often receive an adjunctive anti-arrhythmic therapy. We propose that an addition of spironolactone will reduce the number of clinically significant ventricular arrhythmias and ICD-related therapies. Methods and results In a multicentre retrospective study, 64 patients with ischaemic and non-ischaemic dilated cardiomyopathy whose left ventricular ejection fraction (LVEF) was
ISSN:0019-4832
DOI:10.1016/S0019-4832(12)60044-3