Endoplasmic reticulum stress in diethylnitrosamine-induced rat liver cancer

To analyze the significance of endoplasmic reticulum stress (ERS) in the development of diethylnitrosamine (DEN)-induced liver cancer in rats, critical regulatory factors in ERS signaling pathways were investigated in the present study. The results showed that the expression of ERS-related proteins...

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Bibliographic Details
Published in:Oncology letters 2014-01, Vol.7 (1), p.23-27
Main Authors: XIAO, BIN, CUI, LI-MIN, MA, DONG-JIE, LIU, SHUANG-PING, ZHANG, XUE-WU
Format: Article
Language:English
Subjects:
Biotechnology
Development and progression
diethylnitrosamine
Endoplasmic reticulum
endoplasmic reticulum stress
Gene expression
Health aspects
Kinases
Liver cancer
Liver cirrhosis
rats
Rodents
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Summary:To analyze the significance of endoplasmic reticulum stress (ERS) in the development of diethylnitrosamine (DEN)-induced liver cancer in rats, critical regulatory factors in ERS signaling pathways were investigated in the present study. The results showed that the expression of ERS-related proteins gradually increased in the early and mid-term stages of carcinogenesis, while in the later stages, the expression of these proteins did not change significantly after reaching a peak. ERS is involved in DEN-induced rat liver injury, the proliferation of liver cells and the occurrence and development of liver cirrhosis. However, ERS did not affect hepatoma cell growth following the formation of rat liver cancer in the current study.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2013.1651