Prognostic factors associated with locally recurrent rectal cancer following primary surgery (Review)

Locally recurrent rectal cancer (LRRC) is defined as an intrapelvic recurrence following a primary rectal cancer resection, with or without distal metastasis. The treatment of LRRC remains a clinical challenge. LRRC has been regarded as an incurable disease state leading to a poor quality of life an...

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Bibliographic Details
Published in:Oncology letters 2014-01, Vol.7 (1), p.10-16
Main Authors: CAI, YANTAO, LI, ZHENYANG, GU, XIAODONG, FANG, YANTIAN, XIANG, JIANBIN, CHEN, ZONGYOU
Format: Article
Language:English
Subjects:
Cancer recurrence
Care and treatment
Clinical trials
Colorectal cancer
Development and progression
Health aspects
Health risk assessment
local recurrence
Medical prognosis
Oncology
Patient outcomes
Prognosis
Quality of life
rectal carcinoma
Rectal resection
Risk factors
Surgery
Surgical outcomes
Tumors
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Summary:Locally recurrent rectal cancer (LRRC) is defined as an intrapelvic recurrence following a primary rectal cancer resection, with or without distal metastasis. The treatment of LRRC remains a clinical challenge. LRRC has been regarded as an incurable disease state leading to a poor quality of life and a limited survival time. However, curative reoperations have proved beneficial for treating LRRC. A complete resection of recurrent tumors (R0 resection) allows the treatment to be curative rather than palliative, which is a milestone in medicine. In LRRC cases, the difficulty of achieving an R0 resection is associated with the post-operative prognosis and is affected by several clinical factors, including the staging of the local recurrence (LR), accompanying symptoms, patterns of tumors and combined therapy. The risk factors following primary surgery that lead to an increased rate of LR are summarized in this study, including the surgical, pathological and therapeutic factors.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2013.1640