Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer

Mixed lineage kinases (MLKs) are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family and are reported to activate MAP kinase pathways. There have been at least 9 members of the MLK family identified to date, although the physiological functions of all the family members are...

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Bibliographic Details
Published in:Genes & cancer 2013-09, Vol.4 (9-10), p.334-341
Main Authors: Rana, Ajay, Rana, Basabi, Mishra, Rajakishore, Sondarva, Gautam, Rangasamy, Velusamy, Das, Subhasis, Viswakarma, Navin, Kanthasamy, Anumantha
Format: Article
Language:English
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Summary:Mixed lineage kinases (MLKs) are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family and are reported to activate MAP kinase pathways. There have been at least 9 members of the MLK family identified to date, although the physiological functions of all the family members are yet unknown. However, MLKs in general have been implicated in neurodegenerative diseases, including Parkinson and Alzheimer diseases. Recent reports suggest that some of the MLK members could play a role in cancer via modulating cell migration, invasion, cell cycle, and apoptosis. This review article will first describe the biology of MLK members and then discuss the current progress that relates to their functions in cancer.
ISSN:1947-6019
1947-6027
DOI:10.1177/1947601913485415