Magnolia Extract (BL153) Ameliorates Kidney Damage in a High Fat Diet-Induced Obesity Mouse Model

• Published in: Oxidative medicine and cellular longevity 2013-01, Vol.2013 (2013), p.1-9
• Main Authors: Cui, Wen-peng, Wang, Yang-wei, Chen, Qiang, Sun, Weixia, Cai, Lu, Tan, Yi, Kim, Ki-Soo, Kim, Ki Ho, Kim, Young Heui
• Format: Article
• Language: English
• Subjects: Animals; Diet, High-Fat; Disease Models, Animal; Hexokinase - metabolism; Inflammation - pathology; Kidney - drug effects; Kidney - enzymology; Kidney - pathology; Kidney - physiopathology; Kidney Function Tests; Magnolia - chemistry; Male; Mice; Mice, Inbred C57BL; Models, Biological; NAD(P)H Dehydrogenase (Quinone) - metabolism; Obesity - enzymology; Obesity - pathology; Obesity - physiopathology; Oxidative Stress - drug effects; Plant Extracts - pharmacology; PPAR gamma - metabolism; Protective Agents - pharmacology; Protective Agents - therapeutic use; Up-Regulation - drug effects
• ISSN: 1942-0900; 1942-0994
• DOI: 10.1155/2013/367040

Accumulating evidence demonstrated that obesity is a risk factor for renal structural and functional changes, leading to the end-stage renal disease which imposes a heavy economic burden on the community. However, no effective therapeutic method for obesity-associated kidney disease is available. In the present study, we explored the therapeutic potential of a magnolia extract (BL153) for treating obesity-associated kidney damage in a high fat diet- (HFD-) induced mouse model. The results showed that inflammation markers (tumor necrosis factor-α and plasminogen activator inhibitor-1) and oxidative stress markers (3-nitrotyrosine and 4-hydroxy-2-nonenal) were all significantly increased in the kidney of HFD-fed mice compared to mice fed with a low fat diet (LFD). Additionally, proteinuria and renal structure changes in HFD-fed mice were much more severe than that in LFD-fed mice. However, all these alterations were attenuated by BL153 treatment, accompanied by upregulation of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and hexokinase II (HK II) expression in the kidney. The present study indicates that BL153 administration may be a novel approach for renoprotection in obese individuals by antiinflammation and anti-oxidative stress most likely via upregulation of PGC-1α and HK II signal in the kidney.