Neurological and cellular regulation of visceral hypersensitivity induced by chronic stress and colonic inflammation in rats

Highlights • Novel findings on visceral hypersensitivity, inflammation and stress. • Chronic stress exacerbates hypersensitivity in the presence of inflammation. • Chronic stress downregulated select Kv channels in DRG neurons. • Chronic stress upregulated TRPA1 and NGF in colon muscularis externae....

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2013-09, Vol.248, p.469-478
Main Authors: Chen, J, Winston, J.H, Sarna, S.K
Format: Article
Language:English
Subjects:
abdominal pain
Animals
Biological and medical sciences
Brain-Derived Neurotrophic Factor - genetics
chronic stress
Colitis, Ulcerative - chemically induced
Colitis, Ulcerative - genetics
Colitis, Ulcerative - immunology
Colitis, Ulcerative - physiopathology
colon inflammation
Dextran Sulfate - adverse effects
Dilatation, Pathologic
Down-Regulation
Fundamental and applied biological sciences. Psychology
Ganglia, Spinal - physiopathology
Inflammation - chemically induced
Inflammation - physiopathology
inflammatory bowel disease
Male
Neurology
Neurons - cytology
Neurons - metabolism
Rats
Rats, Sprague-Dawley
RNA, Messenger
sensory neurons
TRPV Cation Channels - genetics
Up-Regulation
Vertebrates: nervous system and sense organs
Visceral Afferents - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Novel findings on visceral hypersensitivity, inflammation and stress. • Chronic stress exacerbates hypersensitivity in the presence of inflammation. • Chronic stress downregulated select Kv channels in DRG neurons. • Chronic stress upregulated TRPA1 and NGF in colon muscularis externae. • TRPA1 antagonist suppressed the sensitization of afferent neurons.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.06.024