Neurotoxicity of immunosuppressive therapies in organ transplantation

Immunosuppressive agents have revolutionized clinical transplantation medicine, allowing the avoidance of immune system attack on the transplanted graft. Nevertheless, the use of medications such as cyclosporine, tacrolimus and others also brought the side effects of these drugs. Early identificatio...

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Bibliographic Details
Published in:Mædica 2013-06, Vol.8 (2), p.170-175
Main Authors: Anghel, Daniela, Tanasescu, Radu, Campeanu, Ana, Lupescu, Ioana, Podda, Giulio, Bajenaru, Ovidiu
Format: Article
Language:English
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Summary:Immunosuppressive agents have revolutionized clinical transplantation medicine, allowing the avoidance of immune system attack on the transplanted graft. Nevertheless, the use of medications such as cyclosporine, tacrolimus and others also brought the side effects of these drugs. Early identification of drug-induced neurotoxicity in transplanted patients and of its specific causes is important, not only because of patient's poor clinical status but because of concomitant systemic and metabolic disorders which may obscure symptoms. Treatment and prognosis are highly dependent on the type of complication and it's early recognition. This review focuses on the clinical entities of neurotoxicity caused by immunosuppressive drugs in transplanted patients.
ISSN:1841-9038
2069-6116