Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome

It is widely accepted that melanin formation may play an immunologic role in invertebrates and ectothermic vertebrates. In farmed Atlantic salmon, cardiomyopathy syndrome (CMS) is a common viral disease associated with severe cardiac inflammation that may be accompanied by heavy melanisation of the...

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Bibliographic Details
Published in:Veterinary research (Paris) 2013-11, Vol.44 (1), p.107-107, Article 107
Main Authors: Fagerland, Hilde A S, Austbø, Lars, Fritsvold, Camilla, Alarcon, Marta, Rimstad, Espen, Falk, Knut, Taksdal, Torunn, Koppang, Erling O
Format: Article
Language:English
Subjects:
Animals
Atlantic salmon
Cardiomyopathy
Development and progression
Fish Diseases - pathology
Fish Diseases - physiopathology
Fish Diseases - virology
Fish Proteins - genetics
Fish Proteins - metabolism
Free radicals (Chemistry)
Genetic aspects
Heart diseases
Immune response
Inflammation
Intramolecular Oxidoreductases - genetics
Intramolecular Oxidoreductases - metabolism
Laser Capture Microdissection - veterinary
Melanins - metabolism
Monophenol Monooxygenase - genetics
Monophenol Monooxygenase - metabolism
Myocarditis - pathology
Myocarditis - physiopathology
Myocarditis - veterinary
Myocarditis - virology
Myocardium - immunology
Myocardium - pathology
Norway
Physiological aspects
Real-Time Polymerase Chain Reaction - veterinary
RNA Virus Infections - pathology
RNA Virus Infections - physiopathology
RNA Virus Infections - veterinary
RNA Virus Infections - virology
Salmo salar
Short Report
Totiviridae - physiology
Virus diseases
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Summary:It is widely accepted that melanin formation may play an immunologic role in invertebrates and ectothermic vertebrates. In farmed Atlantic salmon, cardiomyopathy syndrome (CMS) is a common viral disease associated with severe cardiac inflammation that may be accompanied by heavy melanisation of the heart. By the use of histology, laser capture microdissection and transcription analysis of tyrosinase genes, we here show that this melanisation is linked to de novo melanogenesis by melanomacrophages, suggesting an active part in the inflammatory reaction. No general systemic activation of the extracutaneous pigmentary system in response to viral infections with affinity to the heart was observed.
ISSN:1297-9716
0928-4249
1297-9716
DOI:10.1186/1297-9716-44-107