Inhibition of the in vivo Parathyroid Hormone-Mediated Calcemic Response in Rats by a Synthetic Hormone Antagonist

The parathyroid hormone (PTH) analog, [Tyr34]bovine PTH-(7-34)-amide, can inhibit the PTH-mediated elevation of plasma calcium in thyroparathyroidectomized rats in vivo. The analog is devoid of PTH-like agonist activity in this system. Repeated doses of analog inhibit the animal's calcemic resp...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1986-10, Vol.83 (19), p.7557-7560
Main Authors: Doppelt, Samuel H., Neer, Robert M., Nussbaum, Samuel R., Federico, Panfilo, Potts, John T., Rosenblatt, Michael
Format: Article
Language:English
Subjects:
Agonists
Animals
Biological and medical sciences
Biological Assay
Bones
Calcium
Calcium - blood
Calcium - pharmacology
Dosage
Fundamental and applied biological sciences. Psychology
Hormone antagonists
Hormones
Hormones - pharmacology
Hormones. Regulation
Intravenous injections
Parathyroid Hormone - antagonists & inhibitors
Parathyroid Hormone - pharmacology
Peptide Fragments - pharmacology
Phosphates
Rats
Receptors
Thyroid. Parathyroid. Ultimobranchial body
Time Factors
Vehicles
Vertebrates: endocrinology
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Summary:The parathyroid hormone (PTH) analog, [Tyr34]bovine PTH-(7-34)-amide, can inhibit the PTH-mediated elevation of plasma calcium in thyroparathyroidectomized rats in vivo. The analog is devoid of PTH-like agonist activity in this system. Repeated doses of analog inhibit the animal's calcemic response to PTH. The elevation in serum calcium levels mediated by PTH in this assay reflects PTH action (calcium mobilization) on bone. Earlier studies demonstrated antagonist properties of the analog in a renal-based assay; PTH-stimulated increases in urinary phosphate and cyclic AMP excretion were completely inhibited by the synthetic analog. Along with previous studies, this report indicates that [Tyr34]bovine PTH-(7-34)-amide, is an effective in vivo antagonist for several major parameters of PTH action in both kidney and bone.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.83.19.7557