A pilot study: The importance of inter-individual differences in inorganic arsenic metabolism for birth weight outcome

Highlights • Women in an inorganic arsenic (iAs) endemic area show distinct metabolic patterns. • Underlying iAs methylation efficiency did not distinguish birth weight outcome. • Underlying partitioning of iAs toward excretion characterized birth weight outcome. • Evidence suggests a potential urin...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2013-11, Vol.36 (3), p.1266-1275
Main Authors: Gelmann, Elyssa R, Gurzau, Eugen, Gurzau, Anca, Goessler, Walter, Kunrath, Julie, Yeckel, Catherine W, McCarty, Kathleen M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
Arsenic
Arsenicals - analysis
Arsenicals - metabolism
Arsenicals - urine
Biomarker
Birth weight
Birth Weight - drug effects
Drinking Water - analysis
Emergency
Female
Humans
Infant
Methylation
Methylation ratio
Nails - chemistry
Pilot Projects
Pregnancy
Romania
Romania - epidemiology
Socioeconomic Factors
Spectrophotometry, Atomic
Water Pollutants, Chemical - adverse effects
Young Adult
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Summary:Highlights • Women in an inorganic arsenic (iAs) endemic area show distinct metabolic patterns. • Underlying iAs methylation efficiency did not distinguish birth weight outcome. • Underlying partitioning of iAs toward excretion characterized birth weight outcome. • Evidence suggests a potential urinary iAs biomarker for low birth weight outcome.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2013.10.006