Platelet-derived growth factor receptor (PDGFR) expression in primary spinal cord gliomas

Abnormal signaling through the platelet-derived growth factor receptor (PDGFR) has been proposed as a possible mechanism of spinal cord glioma initiation and progression. However, the extent of PDGFR expression in human spinal cord gliomas remains unknown. In this study we perform immunohistochemica...

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Bibliographic Details
Published in:Journal of neuro-oncology 2012-01, Vol.106 (2), p.235-242
Main Authors: Ellis, Jason A., Canoll, Peter, McCormick, Paul C., Feldstein, Neil A., Anderson, Richard C., Angevine, Peter D., Kaiser, Michael G., Bruce, Jeffrey N., Ogden, Alfred T.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Astrocytoma
Brain tumors
Child
Child, Preschool
Female
Glioblastoma
Glioma
Glioma - metabolism
Glioma - pathology
Humans
Immunohistochemistry
Laboratory Investigation - Human/Animal Tissue
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Grading
Neurology
oligodendroglioma
Oncology
Platelet-derived growth factor
Platelet-derived growth factor receptors
Receptors, Platelet-Derived Growth Factor - biosynthesis
Signal Transduction - physiology
Spinal cord
Spinal Cord Neoplasms - metabolism
Spinal Cord Neoplasms - pathology
Tumors
Young Adult
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Summary:Abnormal signaling through the platelet-derived growth factor receptor (PDGFR) has been proposed as a possible mechanism of spinal cord glioma initiation and progression. However, the extent of PDGFR expression in human spinal cord gliomas remains unknown. In this study we perform immunohistochemical analysis of PDGFRα expression in a series of 33 primary intramedullary spinal cord gliomas of different types and grades. PDGFRα was seen to be expressed in a significant subset of these tumors across all major glioma types including ependymoma, oligodendroglioma, pilocytic astrocytoma, astrocytoma, and glioblastoma. These results support the hypothesis that growth factor signaling through the PDGFR may be important for the development of at least a subset of human spinal cord gliomas. Further studies investigating the prognostic significance of PDGFR expression as well as the role of PDGF signaling on the development of intramedullary spinal cord gliomas are warranted.
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-011-0666-6