Diamond-Lipid Hybrids Enhance Chemotherapeutic Tolerance and Mediate Tumor Regression

Self‐assembled nanodiamond‐lipid hybrid particles (NDLPs) harness the potent interaction between the nanodiamond (ND)‐surface and small molecules, while providing a mechanism for cell‐targeted imaging and therapy of triple negative breast cancers. Epidermal growth factor receptor‐targeted NDLPs are...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2013-07, Vol.25 (26), p.3532-3541
Main Authors: Moore, Laura, Chow, Edward Kai-Hua, Osawa, Eiji, Bishop, J. Michael, Ho, Dean
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biocompatibility
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Cancer
Cell Line, Tumor
drug delivery
Drug Tolerance
Female
Humans
hybrid nanomaterials
Imaging
Lipids - chemistry
Mice
Nanocomposites
nanodiamond
Nanodiamonds - chemistry
Nanomaterials
nanomedicine
Nanostructure
Receptor, Epidermal Growth Factor - metabolism
Regression
Tumors
Xenograft Model Antitumor Assays
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Summary:Self‐assembled nanodiamond‐lipid hybrid particles (NDLPs) harness the potent interaction between the nanodiamond (ND)‐surface and small molecules, while providing a mechanism for cell‐targeted imaging and therapy of triple negative breast cancers. Epidermal growth factor receptor‐targeted NDLPs are highly biocompatible particles that provide cell‐specific imaging, promote tumor retention of ND‐complexes, prevent epirubicin toxicities and mediate regression of triple negative breast cancers.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201300343