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Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication
The mechanism of epigenetic inheritance following DNA replication may involve dissociation of chromosomal proteins from parental DNA and reassembly on daughter strands in a specific order. Here we investigated the behaviour of different types of chromosomal proteins using newly developed methods tha...
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| Published in: | Nature communications 2013-11, Vol.4 (1), p.2841-2841, Article 2841 |
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| creator | Petruk, Svetlana Black, Kathryn L. Kovermann, Sina K. Brock, Hugh W. Mazo, Alexander |
| description | The mechanism of epigenetic inheritance following DNA replication may involve dissociation of chromosomal proteins from parental DNA and reassembly on daughter strands in a specific order. Here we investigated the behaviour of different types of chromosomal proteins using newly developed methods that allow assessment of the assembly of proteins during DNA replication. Unexpectedly, most chromatin-modifying proteins tested, including methylases, demethylases, acetyltransferases and a deacetylase, are found in close proximity to PCNA or associate with short nascent DNA. Histone modifications occur in a temporal order following DNA replication, mediated by complex activities of different enzymes. In contrast, components of several major nucleosome-remodelling complexes are dissociated from parental DNA, and are later recruited to nascent DNA following replication. Epigenetic inheritance of gene expression patterns may require many aspects of chromatin structure to remain in close proximity to the replication complex followed by reassembly on nascent DNA shortly after replication.
Chromatin marks have to be re-established after DNA replication. Here Petruk
et al.
show that many histone-modifying enzymes are found in close proximity to newly replicated DNA in cells of
Drosophila
embryos before the corresponding histone marks are re-established. |
| doi_str_mv | 10.1038/ncomms3841 |
| format | article |
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Chromatin marks have to be re-established after DNA replication. Here Petruk
et al.
show that many histone-modifying enzymes are found in close proximity to newly replicated DNA in cells of
Drosophila
embryos before the corresponding histone marks are re-established.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms3841</identifier><identifier>PMID: 24276476</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 14/63 ; 631/337/100/101 ; 631/337/100/2285 ; 631/337/176 ; 631/337/641/151 ; 64/24 ; 82 ; 82/1 ; 82/29 ; Animals ; Chromatin - genetics ; Chromatin - metabolism ; DNA - genetics ; DNA - metabolism ; DNA Replication ; Drosophila - enzymology ; Drosophila - genetics ; Drosophila - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Epigenesis, Genetic ; Histone Deacetylase 1 - genetics ; Histone Deacetylase 1 - metabolism ; Histones - genetics ; Histones - metabolism ; Humanities and Social Sciences ; Methylation ; Methyltransferases - genetics ; Methyltransferases - metabolism ; multidisciplinary ; Polycomb-Group Proteins - genetics ; Polycomb-Group Proteins - metabolism ; Science ; Science (multidisciplinary)</subject><ispartof>Nature communications, 2013-11, Vol.4 (1), p.2841-2841, Article 2841</ispartof><rights>Springer Nature Limited 2013</rights><rights>Copyright Nature Publishing Group Nov 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-bb8728f5d37cb56e242376b8964700fb828a77bc2d2291a5dd23318efe61f7c93</citedby><cites>FETCH-LOGICAL-c442t-bb8728f5d37cb56e242376b8964700fb828a77bc2d2291a5dd23318efe61f7c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1461705985/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1461705985?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24276476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petruk, Svetlana</creatorcontrib><creatorcontrib>Black, Kathryn L.</creatorcontrib><creatorcontrib>Kovermann, Sina K.</creatorcontrib><creatorcontrib>Brock, Hugh W.</creatorcontrib><creatorcontrib>Mazo, Alexander</creatorcontrib><title>Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>The mechanism of epigenetic inheritance following DNA replication may involve dissociation of chromosomal proteins from parental DNA and reassembly on daughter strands in a specific order. Here we investigated the behaviour of different types of chromosomal proteins using newly developed methods that allow assessment of the assembly of proteins during DNA replication. Unexpectedly, most chromatin-modifying proteins tested, including methylases, demethylases, acetyltransferases and a deacetylase, are found in close proximity to PCNA or associate with short nascent DNA. Histone modifications occur in a temporal order following DNA replication, mediated by complex activities of different enzymes. In contrast, components of several major nucleosome-remodelling complexes are dissociated from parental DNA, and are later recruited to nascent DNA following replication. Epigenetic inheritance of gene expression patterns may require many aspects of chromatin structure to remain in close proximity to the replication complex followed by reassembly on nascent DNA shortly after replication.
Chromatin marks have to be re-established after DNA replication. Here Petruk
et al.
show that many histone-modifying enzymes are found in close proximity to newly replicated DNA in cells of
Drosophila
embryos before the corresponding histone marks are re-established.</description><subject>13/51</subject><subject>14/63</subject><subject>631/337/100/101</subject><subject>631/337/100/2285</subject><subject>631/337/176</subject><subject>631/337/641/151</subject><subject>64/24</subject><subject>82</subject><subject>82/1</subject><subject>82/29</subject><subject>Animals</subject><subject>Chromatin - genetics</subject><subject>Chromatin - metabolism</subject><subject>DNA - genetics</subject><subject>DNA - metabolism</subject><subject>DNA Replication</subject><subject>Drosophila - enzymology</subject><subject>Drosophila - genetics</subject><subject>Drosophila - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Epigenesis, Genetic</subject><subject>Histone Deacetylase 1 - genetics</subject><subject>Histone Deacetylase 1 - metabolism</subject><subject>Histones - genetics</subject><subject>Histones - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Methylation</subject><subject>Methyltransferases - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petruk, Svetlana</au><au>Black, Kathryn L.</au><au>Kovermann, Sina K.</au><au>Brock, Hugh W.</au><au>Mazo, Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2013-11-26</date><risdate>2013</risdate><volume>4</volume><issue>1</issue><spage>2841</spage><epage>2841</epage><pages>2841-2841</pages><artnum>2841</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>The mechanism of epigenetic inheritance following DNA replication may involve dissociation of chromosomal proteins from parental DNA and reassembly on daughter strands in a specific order. Here we investigated the behaviour of different types of chromosomal proteins using newly developed methods that allow assessment of the assembly of proteins during DNA replication. Unexpectedly, most chromatin-modifying proteins tested, including methylases, demethylases, acetyltransferases and a deacetylase, are found in close proximity to PCNA or associate with short nascent DNA. Histone modifications occur in a temporal order following DNA replication, mediated by complex activities of different enzymes. In contrast, components of several major nucleosome-remodelling complexes are dissociated from parental DNA, and are later recruited to nascent DNA following replication. Epigenetic inheritance of gene expression patterns may require many aspects of chromatin structure to remain in close proximity to the replication complex followed by reassembly on nascent DNA shortly after replication.
Chromatin marks have to be re-established after DNA replication. Here Petruk
et al.
show that many histone-modifying enzymes are found in close proximity to newly replicated DNA in cells of
Drosophila
embryos before the corresponding histone marks are re-established.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24276476</pmid><doi>10.1038/ncomms3841</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Nature; Publicly Available Content (ProQuest); PubMed Central; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 13/51 14/63 631/337/100/101 631/337/100/2285 631/337/176 631/337/641/151 64/24 82 82/1 82/29 Animals Chromatin - genetics Chromatin - metabolism DNA - genetics DNA - metabolism DNA Replication Drosophila - enzymology Drosophila - genetics Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Epigenesis, Genetic Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Histones - genetics Histones - metabolism Humanities and Social Sciences Methylation Methyltransferases - genetics Methyltransferases - metabolism multidisciplinary Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism Science Science (multidisciplinary) |
| title | Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication |
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