TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation

In the adult mammalian brain, neural stem cells in the subventricular zone continuously generate new neurons for the olfactory bulb. Cell fate commitment in these adult neural stem cells is regulated by cell fate-determining proteins. Here, we show that the cell fate-determinant TRIM32 is upregulate...

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Bibliographic Details
Published in:Cell death & disease 2013-12, Vol.4 (12), p.e976-e976
Main Authors: Hillje, A-L, Pavlou, M A S, Beckmann, E, Worlitzer, M M A, Bahnassawy, L, Lewejohann, L, Palm, T, Schwamborn, J C
Format: Article
Language:English
Subjects:
631/136/142
631/136/368
631/378/2571/2579
631/80/86
Adult Stem Cells - cytology
Adult Stem Cells - metabolism
Animals
Antibodies
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell Differentiation - genetics
Cell Differentiation - physiology
Cell Line, Tumor
Immunohistochemistry
Immunology
Life Sciences
Mice
Neural Stem Cells - cytology
Neural Stem Cells - metabolism
Neurons - cytology
Neurons - metabolism
Original
original-article
Reverse Transcriptase Polymerase Chain Reaction
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
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Summary:In the adult mammalian brain, neural stem cells in the subventricular zone continuously generate new neurons for the olfactory bulb. Cell fate commitment in these adult neural stem cells is regulated by cell fate-determining proteins. Here, we show that the cell fate-determinant TRIM32 is upregulated during differentiation of adult neural stem cells into olfactory bulb neurons. We further demonstrate that TRIM32 is necessary for the correct induction of neuronal differentiation in these cells. In the absence of TRIM32, neuroblasts differentiate slower and show gene expression profiles that are characteristic of immature cells. Interestingly, TRIM32 deficiency induces more neural progenitor cell proliferation and less cell death. Both effects accumulate in an overproduction of adult-generated olfactory bulb neurons of TRIM32 knockout mice. These results highlight the function of the cell fate-determinant TRIM32 for a balanced activity of the adult neurogenesis process.
ISSN:2041-4889
2041-4889
DOI:10.1038/cddis.2013.487