MMP-8 overexpression and persistence of neutrophils relate to stress-impaired healing and poor collagen architecture in mice

• Published in: Brain, behavior, and immunity behavior, and immunity, 2013-02, Vol.28, p.44-48
• Main Authors: Gajendrareddy, Praveen K, Engeland, Christopher G, Junges, Roger, Horan, Michael P, Rojas, Isolde G, Marucha, Phillip T
• Format: Article
• Language: English
• Subjects: Allergy and Immunology; Animals; Collagen; Collagen - metabolism; Collagen - ultrastructure; Female; Gelatinase A; Gelatinase B; Gene expression; Gene Expression - physiology; Leukocytes (neutrophilic); Matrix metalloproteinase; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 2 - physiology; Matrix Metalloproteinase 8 - metabolism; Matrix Metalloproteinase 8 - physiology; Matrix Metalloproteinase 9 - metabolism; Matrix Metalloproteinase 9 - physiology; Mice; Mifepristone; MMP; Neutrophil collagenase; Neutrophils - physiology; Polymerase chain reaction; Psychiatry; Psychological stress; Real-Time Polymerase Chain Reaction; Remodeling; RU486; Scarring; Stress; Stress, Psychological - physiopathology; TIMP; Tissue inhibitor of metalloproteinase 1; Tissue inhibitor of metalloproteinase 2; Tissue Inhibitor of Metalloproteinase-1 - metabolism; Tissue Inhibitor of Metalloproteinase-1 - physiology; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Tissue Inhibitor of Metalloproteinase-2 - physiology; Tissue inhibitor of metalloproteinases; Wound healing; Wound Healing - physiology
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2012.10.016

Highlight ► Stress causes acute wounds to heal and scar more like chronic wounds via dysregulation of MMP-8, TIMP-1, and neutrophil levels in the wound.