Prognostic value of the BRAF V600E mutation in papillary thyroid carcinoma

The aim of the present study was to investigate the prevalence of the BRAF V600E mutation in papillary thyroid carcinoma (PTC) and to determine the correlation between this mutation and indicators of poor prognosis and outcome in patients with PTC. The BRAF V600E mutation status was analyzed in 187...

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Bibliographic Details
Published in:Oncology letters 2014-02, Vol.7 (2), p.439-443
Main Authors: HE, GUOPING, ZHAO, BAOJIAN, ZHANG, XU, GONG, RIXIANG
Format: Article
Language:English
Subjects:
Age
BRAF V600E
Care and treatment
Deoxyribonucleic acid
Diagnosis
DNA
Gender
Gene mutation
Genes
Genetic aspects
Health aspects
Identification and classification
Liquid chromatography
Lymphatic system
Medical prognosis
Metastasis
Mutation
Oncology
papillary thyroid carcinoma
Patients
prognostic value
Risk factors
Software
Statistical analysis
Studies
Thermal cycling
Thyroid cancer
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Summary:The aim of the present study was to investigate the prevalence of the BRAF V600E mutation in papillary thyroid carcinoma (PTC) and to determine the correlation between this mutation and indicators of poor prognosis and outcome in patients with PTC. The BRAF V600E mutation status was analyzed in 187 tumor samples using the multiplex allele-specific PCR method. Univariate and multivariate analyses were performed to investigate the association of the BRAF V600E mutation with clinical features and patient outcome. The sensitivity of the multiplex allele-specific PCR combined with denaturing high-performance liquid chromatography reached ~1%. The BRAF V600E mutation was observed in 63.6% (119/187) of tumor tissues, predominantly in PTC specimens, and no BRAF mutation was identified in other benign-type thyroid diseases. The univariate analysis indicated that the BRAF V600E mutation was associated with age, tumor stage and prognosis (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2013.1713